ID A0A3Q2KN93_HORSE Unreviewed; 3661 AA.
AC A0A3Q2KN93;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Vacuolar protein sorting 13 homolog C {ECO:0000313|Ensembl:ENSECAP00000024635.1};
GN Name=VPS13C {ECO:0000313|Ensembl:ENSECAP00000024635.1,
GN ECO:0000313|VGNC:VGNC:24915};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024635.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024635.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024635.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024635.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024635.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000064024.3; ENSECAP00000024635.1; ENSECAG00000017182.4.
DR VGNC; VGNC:24915; VPS13C.
DR GeneTree; ENSGT00950000183083; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000017182; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2KN93; baseline.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF125; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 3.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..370
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 569..790
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1133..1231
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1649..1746
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 2441..2975
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 3235..3412
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3418..3501
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3506..3611
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 830..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3661 AA; 410985 MW; 6CF16C71544EC24F CRC64;
MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGDVALDN LQIKENALSE LDVPFKVKAG
QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA EKEEKSLQDI KQKELSRIEE
ALQKAAEKDK PKEAKKDTFL EKLATQVIKN IQVKITDIHI KYEDDVTDPK QPLSFGVTLG
ELSLLTANKQ WTPCILNEAE KIIYKLIRLD SLSAYWNVNC SVSYRRSREQ ILDQLKSEIL
TSSKIPPNHQ YIFQPISASA KLYMNPYAET ELKTPKLDWN IEVQNIAIEL TKPQYLSMID
LLESVDYMVR NAPYRKYKPY LPLHTNGRQW WKYAIDSVLE VHIRRYTQMW SWSNIKKHRQ
LLKSYKNAYK NKLTQTKISE EIQKQIQDLE KTLDVFNIIL ARQQAQVEVI RSGQKLRKKS
ADTGEKRGGW FSGFWGKKES RKKDEESLIP ETIDDLMTPE EKDKLFTAIG YSESTHDLTL
PKQYVAHIMT LKLVSTSVTI RENKNIPEIL KIQIIGLGTQ VSQRPGAQAL KVEAKLEHWY
ITGLRQQDIV PSLVASIGDT ASSLLKIEFE TNPENSTADQ TLIVQSQPVE VIYDAKTINA
VVEFFQSDKG LDLEQIKSAT LMKLEEIKER TATGLTHIIE TRKVLDLRIN LKPSYLIVPQ
TGFHHKKSNL LILDFGTFQL NSKDQGLQKT SNSSLEEIMD KAYDKFDVEI KSVQLLFARA
EENWKKCRFQ HPSTMHILQP MDIHVELSKA MVEKDIRMAR FKVSGGLPLM HVRISDKKMR
DVLCLINSIP LPQISSAPSP ERQVSSIPII SDRTKGLLGT SLLLDGVESE SDDEYFDAED
GDTQPGKSKK GSELKKAAEA PNEELINLLL KFEIKEVVLE FTKQEKEENT ILVFNVTQLG
TEATVRTFDL TAVSYLKKIS LDYHEIQGSK KKPLHLISSS DKPGLDLLKV EYIKADKNGP
SFQTTFEKTE QTFKVAFSSL NLLMQTQALL SSINYLTTII PSDGQNIGDT KEVQISTENQ
QKNSALQKVI VSSKDSDIID FRLFAKLNAF CVIICDEKNN IAEIKIQGLD SSLSLQSRKQ
SLFARLENIV VTDIDPNTVH KKAVSIMGNE VFRFNLDLYP HATEGDAYTD MSKVDGVVSL
NVGCIQIVYL HKFLMSLLNF LNNFQTAKEA LSAATAQAAE KAATSVKDLA QRSFRVSINI
DLKAPVIVIP QSSISTNAVV VDLGLIRVQN QFSLVSGEDY LNPPVIDRMD VQLTKLKLSR
TVIQPGISHP DIQLLYPINL EFSVNRNLAS SWYHKVPVVE IKGHLESMNV SLNQEDLNLL
FRILAENLGE ATEDLNKVKP GIQKTGEPKE PLETSVSQQD VRALQSTLTA GVEEIKSVDI
INMVLNFEIK EVVITLMKKA EKKGRPIHEL NVLQLGMEAR VKTYDLTAQA YLKKISMRCF
EFADSKGEPL HIINSSNVTD EPLLKMLLTK ADSDGPEFKT IHENTKQRLK VSFSSLDLVL
HLEALLSFMD FVSSAIPSSE PSYSEKESEL KPLMGESRSI VVKAVSSSTS QDDVFDLKII
AELNAFNVFV CDQKCNIADI RIHGMDASIS VKPKQTDMFA RLKDIIVTNV DLLSIHKKAV
SILGDEVFRF QMTLFPDATE GKAYADMSKV DGKLSLKVGC IQIVYVHKFF MSLLNFLNNF
QTAKEALSAA TVQAAERAAS SMKDLAQKSF RLLMDINLKA PVIIIPQSSV SPNAVIADLG
LIRVENKFSL VSVGHYSLPP VIDKMNIQLT QLKLSRTILQ AGLPQHDIEI LKPVNMLLSI
QRNLAATWYT QIPGMEIKGK LKPMQVALSE DDLTVLMKIL LENLGEASSQ PSPTQSTQEA
VRVRKDVSSG PDHLKAQEDL PDSELSVDQN VTLQFDFHFE SLSIVLYNND VNQESKLAFH
NDNFRLGELR LHLMASAGKM FKDGSMNVSI KLKTCTLDDL REGIERATSR MIDRKNDQDN
NSSMIDISYK QGKNGSHIDA VLDKLYICAS VEFLMTVADF FIKAVSQSPE NMAKEAQIPL
RQTATAKLRI DKDDSLKPNM TLKAMITDPE VVFVASLTKA DAPALTASFQ CDLSLSTSKL
EQMMEASVRD LKVLACPFLR EKRGKNITTV LQPCSLFMEK CTWASGKQNI NIIVEEFIIK
ISPIILNTVM TIMAALSPKT KEDESKDTSK ETENLWGVKS ISDYNSWFLG VDTATEITEN
FKDIDRPFIE ENCAVVVESV QVTLECGLGH RTVPLLLAES KFSGNIKNWT SLMSAAADMT
LEVHYYNEVH AVWEPLIERV EGKKQWNLRL DVKKNPVQDK SLMPGDDFGF IPEPQTAVHI
SSGDTMNITI SKSCLNVFNN LAKGFSEGTA STFDYSLKDR APFTVKNALG VPVKVQPNHN
LRVMGSPEKS GIYDVDAGQN LELEYASVEP SRQGKLSILN RQESSFFTLT IVPHGYTEVG
KIPVARPGRQ LYNVRNPNAT HSDSVLVQID ATEGNKVITI RSPLQIKNHF SVAFIIYKFV
KNVKLLERIG VARPEEEFHV PLDSYRCQLF IQPAGILENQ YKESTTYISW KEELHRSREV
RCMLQCPSVE INFLPLMVNT VALPDELTYI STHGEDWDPA YVIHLYPTLT LRNLLPYSLR
YLLEGTAETH ELAEGSAADV LHSRISGEIM ELVLMKYQGK NWNGHFRICD TLPEFFLVCF
SSDSTEVMTL DLSVHVRRIG SRMVLSVFSP YWLINKTSRV LQYRSEDIHV KHPADFRDII
LFSFKKKNIF SKNKVQLKIS TSAWSSSFSL DTVGSYGCVK CPANNMEYLV GVSIKMSSFN
LTRIVTLTPF CTIANKSSLE LEVGEIASDG SMPTNKWNYI ASSECLPFWP ENLSGKLCVR
VVGCEGSSKP FFYNRQDNGT LLSLEDLNGG ILVDVNTAEH STVITFSDYH EGSAPALIMN
HTPCGILTYK QSGSQEEVEL QPRQARLFAW ADPTGTRKLT WKYAANVGEH DLLKDECGQF
AYDANIQIHW VSFLDGRQRV LLFTDDVALV SKALQAEEME QANHEITFSL HSLGLSLVNN
ENKQEVSYIG ITSSGVIWEM KPKRKWKPFS QKQIILLEQS YKKYQESRGH GWIKLDNNFE
VDNQLPGTMF PVLFHPVAPP KSIALDSEPK PFIDVSVITR FNEYSKVLQF KYFMVLIQEM
ALKVDQGFLG AITALFTPAT DPEAESKRTK LIQQDVDALN TELMETSMTD MSVLSFFEHF
HISPVKLHLS LSLSSGGEES DKEKQEMIAI HSVNLLLKSI GATLTDVDDL IFKLAYYEIK
YQFYKRDQLM WSVFRHYTEQ FLKQMYVLVL GLDVLGNPFG LIRGLSEGVE ALFYEPFQGA
VQGPEEFAEG LVIGVRSLFG HTVGGAAGVV SRITGSVGKG LAAITMDKEY QQKRREEMGR
QPKDFGDSLA RGGKGFLLGV VGGVTGIITK PVEGAKKEGA AGFFKGIGKG LVGAVARPTG
GIIDMASSTF QGIQRAAEST EEVSSLRPPR LIHEDGIIRP YDRQESEGCD LFENHIKKLE
GEIYRYHCAI PGNKKTILMV TNRRVLCIKE VEILGCMSID WQCPFEDFVV PPSVSGNLLQ
ISVKEQGLFH KKDSANQGYL RKIYLLDTTT AERACKAIED AQSVRHQQKL VKQSSLKLLV
P
//
