ID A0A3Q2KP14_HORSE Unreviewed; 1414 AA.
AC A0A3Q2KP14;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Zinc finger FYVE domain-containing protein {ECO:0000256|PIRNR:PIRNR037289};
GN Name=ZFYVE16 {ECO:0000313|Ensembl:ENSECAP00000024930.3,
GN ECO:0000313|VGNC:VGNC:25228};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024930.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024930.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024930.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024930.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024930.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037289}. Early
CC endosome membrane {ECO:0000256|PIRNR:PIRNR037289}.
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DR Ensembl; ENSECAT00000055110.3; ENSECAP00000024930.3; ENSECAG00000013918.4.
DR VGNC; VGNC:25228; ZFYVE16.
DR GeneTree; ENSGT00940000163574; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000013918; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2KP14; baseline.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd15729; FYVE_endofin; 1.
DR Gene3D; 3.30.1360.220; Domain of unknown function (DUF3480), N-terminal subdomain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR022557; SARA-like_C.
DR InterPro; IPR035438; SARA/endofin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46319; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46319:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF11979; SARA_C; 1.
DR PIRSF; PIRSF037289; SARA/endofin; 1.
DR SMART; SM01421; DUF3480; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037289};
KW Endosome {ECO:0000256|PIRNR:PIRNR037289};
KW Membrane {ECO:0000256|PIRNR:PIRNR037289};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037289};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 752..810
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 645..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1414 AA; 154437 MW; 9D9B88FDC7BE3269 CRC64;
MDSYFKAAVS DLDKLLDDFE QNPDEQDYLQ DAQKAYDSNH CSVSSELASS QLTSLLPKDQ
QCINCASSET CYETNQISLN GKTLEGLTSI QNEKNVTGLD LLSSVDGGTS EEIQPLYVGR
CSKPVCDLIR DMGNLVHVTS SEEDTKKLLP EDFKSSADSL IGLDLSAVSE APCVSSTDHG
NDTVREEEND VISSELQNRE ISGTKELGIK ADTALSDSCN YMGKENLHDQ KISNQLEPVL
DFNTPSALTQ QNSKMFDAKD SLQHKKQPCE LVEADGCSVE EEIHVAVTAA TECLKGGSTN
TLPCSLPKNE GLCLSDSNSG DENFKLPDFS FQEDRTSIFI KQSAKEDSRN LDPKDYKDVI
QDSSSTLHVS GEDTYSSLSC LPVPGSLCGS LVESKAHGDG LPQNEHEDNI HDAVTVHKEI
QKSVLGGEPL KETDLLKQEK CKNVLHQLSA EKMGDRKVDP EQMVIRVESL GYPDNTSCSV
AAESQMELSG ANAPESPDGC EGLAFSSNDI DGQDLDYFNI DEGMKSGMLI SDAELDAFLT
EQYLQTSNIK SFEENVNDSK SQMSQIDMKD LDDGNISNVY FNAEAGATGE SPGINVICET
LDKQNTTENG GLSLGEKSTI PVELGLSSTK SEITNDLSVS DINSQSVHVG GARPKQLFSV
PSRTRSSKEP NKPDAPNVTE SEPSIANTIA PTTCSTDFTT DPQGSFNSNY IDIESNFEGG
SSFVTANEES LPANTCKEGL VLGQKQPTWV PDSEAPNCMN CQVKFTFTKR RHHCRACGKV
FCGVCCNRKC KLQYLEKEAR VCVVCYETIS KAQAFERMMS PTGSSLKSNR SDECATIQPL
QETHTPSLTS PTALPISALK QPCVEGLCSK EQKRVWFADG ILPNGEVADT AKLSSGSKKC
SEDFSPLLPD VPLTVNTVDH ARSTTVEKTN NEIGDITRNE IIQSPISQVP SVEKPPINSG
TEGLPSSGSF TLDDDVFAEI EEPSSPTGVL VNSDLPVASI SDYRLLCDID KHVCNKINLL
PSDEDSLPPL LVSSGEKGSV PVVEEHPSHE QIILLLEGEG FHPVTFVLNA NLLVNVKLVF
YSSDKYWYFS TNGLHGLGQA EIIILLLCLP NEDTIPTDIF RLFITVYKDA LKGKYIENLD
NITFTESFLG SKDHGGFLFI TPTFQKLDDL PLPSNPFLCG ILIQKLEIPW AKVFPMRLML
RLGAEYKAYP APLTSIRGRK PLFGEIGHTI MNLLVDLRNY QYTLHNIDQL LIHMEMGKSC
IKIPRKKYSD VMKVINSSNE HVISIGASFS TEADSHLVCI QNDGVYQTQA SSATGHPRKV
TGASFVVFNG ALKTSSGFLA KSSIVEDGLM VQITPETMEG LRLALREQKD FKITCGKVDA
VDLREYVDIC WVDSEEKGNK GNSLSVCKRN SHGL
//
