ID A0A3Q2KTB1_HORSE Unreviewed; 605 AA.
AC A0A3Q2KTB1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ovochymase 2 {ECO:0000313|Ensembl:ENSECAP00000027181.2};
GN Name=OVCH2 {ECO:0000313|VGNC:VGNC:56769};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000027181.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000027181.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027181.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000027181.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027181.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; A0A3Q2KTB1; -.
DR STRING; 9796.ENSECAP00000027181; -.
DR PaxDb; 9796-ENSECAP00000027181; -.
DR Ensembl; ENSECAT00000031826.2; ENSECAP00000027181.2; ENSECAG00000017959.4.
DR VGNC; VGNC:56769; OVCH2.
DR GeneTree; ENSGT00940000157791; -.
DR InParanoid; A0A3Q2KTB1; -.
DR OMA; GAFQFDH; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000017959; Expressed in trophectoderm and 2 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF13; TRANSMEMBRANE SERINE PROTEASE 12; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059}; Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 83..330
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 342..452
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 462..570
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 462..489
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 605 AA; 66726 MW; F1BF3F7370BF7F30 CRC64;
MQTWDQSLAV PLTVYGITVS LKFQGKTLSL KMPMSKNKLI LLIGMICLEQ GKSATLSLPK
APTCGQSLVK ARPQNYFNIF SRIVGGSQVE KGSYPWQVSL KRRQKHICGG TIISPQWVIT
AAHCVANRNI ALTLNVTAGE YDLNHTEPGE QTLTIETIIV HPHFSTKKPM DYDIALLKMT
GAFNFGQFVR PVCLPEPGER FEAGFICTTA GWGRLTEDGI LSQVLQEVNL PILTQEECVA
ALLTLKKPIS GQTFLCTGFP DGGRDACQGD SGGSLMCRNK KGAWTLAGVT SWGLGCGRGW
RNNVQKDDQG SPGIFTDLSK VLPWVHKHVQ IGKRRKISRA SCSEQDHVVS NSEGQLHFPE
TSYLYYESKQ LCVWTLLVPE AMHVLLIFSH LDAESCYHNH LSIYSLEDRL IGKFCGESLT
SSVLIGANSI RLKFSSDATD YAAGFNLTYK ALKPNYLPDS GCSSLTVLFE EGLIQSLHYP
EDYTNMADCN WIFQAPKHYL IKSLEIEESG DCSSDFVTVH RDVEGKTEIA RLCGFDAPAP
VLSSSGVMLI SFQSDGNVTF RGFQATVSFI PEKDLNISRS EDESMFVETQ NVLSEEPNAS
VLQSI
//
