ID A0A3Q2KTP0_HORSE Unreviewed; 874 AA.
AC A0A3Q2KTP0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=LRR binding FLII interacting protein 1 {ECO:0000313|Ensembl:ENSECAP00000027357.3};
GN Name=LRRFIP1 {ECO:0000313|Ensembl:ENSECAP00000027357.3,
GN ECO:0000313|VGNC:VGNC:56580};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000027357.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000027357.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027357.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000027357.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027357.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LRRFIP family.
CC {ECO:0000256|ARBA:ARBA00008275}.
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DR RefSeq; XP_014595851.1; XM_014740365.1.
DR AlphaFoldDB; A0A3Q2KTP0; -.
DR Ensembl; ENSECAT00000059827.3; ENSECAP00000027357.3; ENSECAG00000016447.4.
DR VGNC; VGNC:56580; LRRFIP1.
DR GeneTree; ENSGT00530000063564; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000016447; Expressed in blood and 23 other cell types or tissues.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.20.5.4090; -; 1.
DR InterPro; IPR019139; LRRFIP1/2.
DR PANTHER; PTHR19212; LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN; 1.
DR PANTHER; PTHR19212:SF5; LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 1; 1.
DR Pfam; PF09738; LRRFIP; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2KTP0};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 74..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 155..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 74..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 97026 MW; 7EDE3DA56FE53B73 CRC64;
MTNPAATQNK EIDCLSPEAQ RLAEARLAAK RAARAEAREI RMKELERQQK EIYQVQKKYY
GLDTKWGDIE QWMEDSERYS RRSRRNTSAS DEDERMSVGS RGSLRVEERG EKDFTEKGSR
SLPSLSAATL ASLGGTSSRR GSGDTSISID TEASIREIKD SLAEVEEKYK KAMVSNAQLD
NEKTNFMYQV DTLKDMMLEL EEQLAESRRQ YEEKNKEFER EKHAHSILQF QFAEVKEALK
QREEMLEKHG IILNSEIATN GETSDTLNNV GAQGPTKMTK EELNALKATG DGTLGRANEV
EVKNEIVENV GKREILQNTE QEQHKEDPIK DYVDTEVLHP GENAEDQKPS EDSAPSLGTL
ANATDEEQVQ SQILENASFL ENTEQVESNE VLNRPDDRTE ASVEESKCWS DLDSEIPGPV
IGQDGCNTLD IENQSKESAE KQEEEKQEDF KTNLGDVSVK PSQESAPLQI SEVERVSGTD
TGEQNGSPTE GVIEAGLTGF EERVGTVASS PPRDSNDTES HDEKCVVDAP KELDPSTGHD
LEKELTNQEV AEPKEIPSQY AEVGGENNEE EDDGRELRGE KPIQMEVQTI PSSPAAEDSA
QQATGPRMVD AEREPLDMKE ADEEKSDQQG EALDSSQKKT KNKKKKNKKK KSPAPVETLK
DVKKELTFQN PDLREVKEEE QVKFTDEKPV VEAQNEVSKN PEQKTVAGNS ENVDCPENPK
IESDGNLNQE DYDVNTKAGK VIADGDTLNF EDDTIQSPDT SDKELDESVI KDDAKADGAT
QSHPPEPEKE EASDSALLEN ESPSNDINDA SQTESTEGHV MSEYPSQIVG KISDSNSLEN
DELALAGELP DSEIGEEIRG RNEKGKSKED CSLS
//
