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Database: UniProt
Entry: A0A3Q2KXS3_HORSE
LinkDB: A0A3Q2KXS3_HORSE
Original site: A0A3Q2KXS3_HORSE 
ID   A0A3Q2KXS3_HORSE        Unreviewed;      2032 AA.
AC   A0A3Q2KXS3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN   Name=LOC100055507 {ECO:0000313|Ensembl:ENSECAP00000029392.3};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000029392.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000029392.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029392.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000029392.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029392.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   Ensembl; ENSECAT00000032421.3; ENSECAP00000029392.3; ENSECAG00000012339.4.
DR   GeneTree; ENSGT00950000182767; -.
DR   Proteomes; UP000002281; Chromosome 30.
DR   Bgee; ENSECAG00000012339; Expressed in liver and 23 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q2KXS3; baseline.
DR   CDD; cd11893; SH3_MIA3; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23158; MELANOMA INHIBITORY ACTIVITY-RELATED; 1.
DR   PANTHER; PTHR23158:SF54; TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1 HOMOLOG; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2KXS3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..2032
FT                   /note="SH3 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040499314"
FT   DOMAIN          45..107
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          154..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..921
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1058..1117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1424..1449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1650..2032
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1226..1281
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1345..1400
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1498..1532
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1565..1645
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        229..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..531
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..624
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..697
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        713..739
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        740..754
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        773..865
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        874..921
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1058..1085
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1089..1107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1662..1677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1738..1752
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1773..1943
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2011..2032
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2032 AA;  225629 MW;  1B8B7E7F6B055201 CRC64;
     MAAAARLLFC LLLLWPPWPG LGLTDLDTGR RFSEHKLCAD EECSMLMVRG EALQDFAGPD
     CRFVNFKKGD PVYVYYKLAG GSPEVWAGSV GRIFGYFPKD LIKVVYEYTK EEIQVPTDET
     DFVCFDGGRD DFDNYNIEEL LGFLEFYDSA PEDSEKAIEE TSQHVNRLPG VSEEKNPDTE
     PVESSSEDNE GVFSENTEEL RGTPEAQKSY PHINGPTDPA QGERSSFEPF EEMLQDKLKV
     PESENNKTSN SSQVSDEQEK MDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE
     DDFDEELDAE HYTVGKEEEE DKENFDEIPL LTFSGGEDTK TPVKSGAEKY STDKEQNSHE
     ERKVMVAQPP GMKNDDKNIL TSLEDSSLFL ATKSEEQRGV DLESSDSKEE KESDDALVPE
     SKQVTPRSAA DYIDPEKAED GPLIVEVSKT NNDKDPEMDP ELHIKEKRKV EDSGRGLVQD
     ETGLEDAKPE GMTVHRAPQS SDLNALPAAE KGKETLKSGF DHKEDDLKGA TVDISEGTLQ
     EEKPGEQILE GGSESGSVHT AAGNPMKEGK IEQESRHSAP LAGDNQHNAS KDSVEGGDVP
     ASGPKPPSLS VEHPHEKLKE ETLLKTQNQP RFSSPDEIGL PRELEEGSPV LGRNLSQQQG
     RDVAAVVNKE ANEKIRRSEE EVKQDPSDED FVHRKPTPGM QEVETTDQND SAEVPDFLDE
     EWEAEDDDYA PEELLEDENA VSAGESKEES PVIQDRQLDV NAQGPERAVL GAVDADPETE
     ENKEETGSLL EIERKNETVG EIDRKPGHMV VEKEGGPLVD EKAQRPSEGS DFPDKKKDET
     PELGEVFEDK DPDYFKEDSP EEHLNTSGLT EKPGGEEVSK EDREDLEKFM DTERQGSASG
     EREDDVFHWP PHWTAKPKQS DKMKDAPIIS SFFKEPQSLQ RFQKYFDIHE LEALFQEMSL
     KLKAAQQESL PYNVEKVLDK VFRASESEIL SIAEKMLDTR VIKNGELGVK ESNIFEEAAV
     LDDVQDLIYF VRYTHSIAEE TVPPAAARRP AEDWDRLMED VPPPREDDFS QEDTEDLKTE
     IPEEPSCLDQ LDQPTTSDVG TSEMSQKPNT EKDIHPGIIT TKRTPVNAVD PRKQQETKAE
     EATSVTPWEN AILLIYSFMF YLTNMLLATL PDDVQPGPDC YGLPWKPVLI TASLGIVSFA
     IFFWRTILVV KSRMYQVTEQ QIAEKLKTIT KENAELVQKL SNYEQKIKES KKRIQETKRQ
     NMILSDEAIK FKDKIRNLEE TNGILDETAK NLHVMLESER EQIAKNQDLI SENKKSIEKL
     KDVISLNASE FSEVQIALNE AKLSEEKVRS ECLRVQEENA KLKKKKEQLQ QEIEDWSKLH
     AELSEQIQSF EKSQKDLEMA VTHKDDKVDA LVNCITQLDR IDCESEPEGQ NKGGNEPGEL
     ANGEVGGDQS ERMKNQIKQM MDVSRTQTAI SLVKEDLKLS QVKLRASMST ECNLKDQIKK
     LEDDRSSLEA AKAGLEAECS TLRQKVEVLN ELYQQKEMAL QKKLSKEEFE RQEKEQRLSV
     ADEKVVLAAE ELKTYKRRIE EMEDELQKTE RSFKNQLAAH EKRAHDNWLK ARAAERAIAE
     EKRESSNLRH KLLEMTQKMA MLQEEPVIVK PMPGRPNMQN APRRGPLSQN GSYGPSPVSG
     GECSPPLTAD PPARPLSATL GRREMPRSEF GSMDGPLPHP RWSSEASGKP SAPDAGSGAA
     PTMNSGSRSS SPAKVAEEGK VNMATKGPPR FPGVPFMGSP VGGPLPPPIR YGPPPQLSGP
     PPPSQYGPPP QLSGPPPPTQ YGPPPQLSGP PPPRQYGPPP QLSGPPPPRQ YGPPPQLSGP
     PAPNQYGPPP QLSGPPPHSQ YGPPPQLSGP PPPRHYGPPP QLSGPPPPIH HGPPPQLCGP
     FGPRPLGPQF GPGPRPPLGV REYAPGVPPG KGDLPVDPRE FLPGHAPFTP PGNFVPREYF
     IPGARLPPPT HDPQDYPPSA ARDLPPSGSR DESPPASQSS GQDSSSALKH SP
//
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