ID A0A3Q2KXS3_HORSE Unreviewed; 2032 AA.
AC A0A3Q2KXS3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN Name=LOC100055507 {ECO:0000313|Ensembl:ENSECAP00000029392.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000029392.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000029392.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029392.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000029392.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029392.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR Ensembl; ENSECAT00000032421.3; ENSECAP00000029392.3; ENSECAG00000012339.4.
DR GeneTree; ENSGT00950000182767; -.
DR Proteomes; UP000002281; Chromosome 30.
DR Bgee; ENSECAG00000012339; Expressed in liver and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2KXS3; baseline.
DR CDD; cd11893; SH3_MIA3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23158; MELANOMA INHIBITORY ACTIVITY-RELATED; 1.
DR PANTHER; PTHR23158:SF54; TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1 HOMOLOG; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2KXS3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2032
FT /note="SH3 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040499314"
FT DOMAIN 45..107
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 154..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1226..1281
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1345..1400
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1498..1532
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1565..1645
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 229..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..739
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1085
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1662..1677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1738..1752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1773..1943
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2011..2032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2032 AA; 225629 MW; 1B8B7E7F6B055201 CRC64;
MAAAARLLFC LLLLWPPWPG LGLTDLDTGR RFSEHKLCAD EECSMLMVRG EALQDFAGPD
CRFVNFKKGD PVYVYYKLAG GSPEVWAGSV GRIFGYFPKD LIKVVYEYTK EEIQVPTDET
DFVCFDGGRD DFDNYNIEEL LGFLEFYDSA PEDSEKAIEE TSQHVNRLPG VSEEKNPDTE
PVESSSEDNE GVFSENTEEL RGTPEAQKSY PHINGPTDPA QGERSSFEPF EEMLQDKLKV
PESENNKTSN SSQVSDEQEK MDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE
DDFDEELDAE HYTVGKEEEE DKENFDEIPL LTFSGGEDTK TPVKSGAEKY STDKEQNSHE
ERKVMVAQPP GMKNDDKNIL TSLEDSSLFL ATKSEEQRGV DLESSDSKEE KESDDALVPE
SKQVTPRSAA DYIDPEKAED GPLIVEVSKT NNDKDPEMDP ELHIKEKRKV EDSGRGLVQD
ETGLEDAKPE GMTVHRAPQS SDLNALPAAE KGKETLKSGF DHKEDDLKGA TVDISEGTLQ
EEKPGEQILE GGSESGSVHT AAGNPMKEGK IEQESRHSAP LAGDNQHNAS KDSVEGGDVP
ASGPKPPSLS VEHPHEKLKE ETLLKTQNQP RFSSPDEIGL PRELEEGSPV LGRNLSQQQG
RDVAAVVNKE ANEKIRRSEE EVKQDPSDED FVHRKPTPGM QEVETTDQND SAEVPDFLDE
EWEAEDDDYA PEELLEDENA VSAGESKEES PVIQDRQLDV NAQGPERAVL GAVDADPETE
ENKEETGSLL EIERKNETVG EIDRKPGHMV VEKEGGPLVD EKAQRPSEGS DFPDKKKDET
PELGEVFEDK DPDYFKEDSP EEHLNTSGLT EKPGGEEVSK EDREDLEKFM DTERQGSASG
EREDDVFHWP PHWTAKPKQS DKMKDAPIIS SFFKEPQSLQ RFQKYFDIHE LEALFQEMSL
KLKAAQQESL PYNVEKVLDK VFRASESEIL SIAEKMLDTR VIKNGELGVK ESNIFEEAAV
LDDVQDLIYF VRYTHSIAEE TVPPAAARRP AEDWDRLMED VPPPREDDFS QEDTEDLKTE
IPEEPSCLDQ LDQPTTSDVG TSEMSQKPNT EKDIHPGIIT TKRTPVNAVD PRKQQETKAE
EATSVTPWEN AILLIYSFMF YLTNMLLATL PDDVQPGPDC YGLPWKPVLI TASLGIVSFA
IFFWRTILVV KSRMYQVTEQ QIAEKLKTIT KENAELVQKL SNYEQKIKES KKRIQETKRQ
NMILSDEAIK FKDKIRNLEE TNGILDETAK NLHVMLESER EQIAKNQDLI SENKKSIEKL
KDVISLNASE FSEVQIALNE AKLSEEKVRS ECLRVQEENA KLKKKKEQLQ QEIEDWSKLH
AELSEQIQSF EKSQKDLEMA VTHKDDKVDA LVNCITQLDR IDCESEPEGQ NKGGNEPGEL
ANGEVGGDQS ERMKNQIKQM MDVSRTQTAI SLVKEDLKLS QVKLRASMST ECNLKDQIKK
LEDDRSSLEA AKAGLEAECS TLRQKVEVLN ELYQQKEMAL QKKLSKEEFE RQEKEQRLSV
ADEKVVLAAE ELKTYKRRIE EMEDELQKTE RSFKNQLAAH EKRAHDNWLK ARAAERAIAE
EKRESSNLRH KLLEMTQKMA MLQEEPVIVK PMPGRPNMQN APRRGPLSQN GSYGPSPVSG
GECSPPLTAD PPARPLSATL GRREMPRSEF GSMDGPLPHP RWSSEASGKP SAPDAGSGAA
PTMNSGSRSS SPAKVAEEGK VNMATKGPPR FPGVPFMGSP VGGPLPPPIR YGPPPQLSGP
PPPSQYGPPP QLSGPPPPTQ YGPPPQLSGP PPPRQYGPPP QLSGPPPPRQ YGPPPQLSGP
PAPNQYGPPP QLSGPPPHSQ YGPPPQLSGP PPPRHYGPPP QLSGPPPPIH HGPPPQLCGP
FGPRPLGPQF GPGPRPPLGV REYAPGVPPG KGDLPVDPRE FLPGHAPFTP PGNFVPREYF
IPGARLPPPT HDPQDYPPSA ARDLPPSGSR DESPPASQSS GQDSSSALKH SP
//