GenomeNet

Database: UniProt
Entry: A0A3Q2KYR7_HORSE
LinkDB: A0A3Q2KYR7_HORSE
Original site: A0A3Q2KYR7_HORSE 
ID   A0A3Q2KYR7_HORSE        Unreviewed;      3029 AA.
AC   A0A3Q2KYR7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   07-OCT-2020, entry version 9.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSECAP00000029918};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSECAP00000029918,
GN   ECO:0000313|VGNC:VGNC:16394};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000029918, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000029918, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029918,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000029918}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029918};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
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DR   Ensembl; ENSECAT00000032495; ENSECAP00000029918; ENSECAG00000024127.
DR   VGNC; VGNC:16394; CENPF.
DR   GeneTree; ENSGT00730000111187; -.
DR   Proteomes; UP000002281; Chromosome 5.
DR   ExpressionAtlas; A0A3Q2KYR7; baseline.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR   GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          1..305
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1818..1960
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2056..2195
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2238..2377
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2896..2938
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          208..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          470..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1442..1461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1593..1612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2816..2996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          278..333
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          341..404
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          416..464
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          503..613
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          645..700
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          766..793
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          826..916
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          956..1011
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1016..1036
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1045..1079
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1123..1171
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1210..1244
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1263..1283
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1321..1341
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1473..1543
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1548..1570
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1716..1778
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1815..1835
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1885..1919
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1934..2024
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2032..2210
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2221..2241
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2249..2392
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2400..2420
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2435..2472
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2480..2535
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2561..2609
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2614..2634
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2643..2750
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2761..2788
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2796..2816
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        208..260
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..491
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1442..1459
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2816..2857
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2864..2879
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2880..2909
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2924..2938
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2961..2996
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3029 AA;  346807 MW;  77A3E23093225A38 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGTNLKRENQ SLMEICENLE KTKQKIAHDL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ TAQSADVSLN PCNTPQKIFA TPLTPSHYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKVSQAIPQS TMNHRDIARH QASSSVFSWQ QEQTPSRLSS SAQKTPIGRD
     FSASHFSGEV TPSRSTLKMG KRDANGSFCE DSSNSYLLDQ LKAQNQELRS KISELELRLQ
     GQEKEMKGQV NKFQELQLQL ERAKVELIEK EKVSNKSRDE LVRTTAQYDQ ASTKCTALEQ
     KLKKLTEDLS CQRQNADSAK RSLEQKIREK EKEFQEELSR QQRSFHTLDQ ECTQMKAKLT
     QELQQAKNMH NILQAELDKG TSAKHQLEKN LEEFKQKFSR TEQAFQASQI KENELRRSSE
     EMKKENSLLK SQSEQRAREV CHLEEELKKA KQCLSQSQNL AEEMKAKTTS QETMLRDLQE
     KINQQENSLT LEKLKLALAD LEKQRDCSQD LLKKREHHIE QLNDKLSKTE RESEALLTAL
     ELKKKECEEL KEEKTLFSRC KSENEQLLKL HQKAEFSDQK HRKEMENMCL KVSQLTGQVE
     DLEHKLQLLS SEIMDKDQRY QDLRAECESL RDQLKSKDSS LVTNEAHHRS LLAFEQQSAM
     SNSFVNIIGE QESVPSERSE CPLKVDQSPK TSSVLQHRVV SLEFSLESQK QMNSDLQKQC
     EELVQIRGEI EENLIKAEQM HQSFVAETSQ RISKLQEDTS VHQNVVAETL VALEDKEREL
     QLLNEKLETE QAETQELKKS NHLLQEALKE LQLLSETLSS EKKEMSSVIS LNKREIEELT
     QENGTLKEIN AALNQEKINL LQKSESFSNC IDERDRSISE LANQYQQERL ILLQKCEETG
     NAFEDLNEKY KAAQEKNSKL ESLLNECTSV CENKKNELEQ LKEAFAREHQ AFVTKLALAE
     ERNQNLILEL GAVQQDLRSE ITDIQNNSKS EADGLKQEIV TLKEEQSKMQ QEVNALLQEN
     EHLIKLMKTE HEHQNLELEP ARDSVKERES EINRCDLQLP MDLEVEDTSL DSYKAQLAQL
     EAKIRNMELK LQESEEEKEC LQRELQTIRG ELQTGSLQQV TQSQEVRGLK DTEEQYISVL
     HELSTSQNDN AHLQCSLQTA MNKLNELEKL CEVLRVEKFE LISELNDSRS ECITATSKMA
     GEVEKLVNEV KMLNDENDLL QGEFVKEMPE GEFGEQQNEQ KSVAVNPLDD GDFCEPLTLS
     NKEVQMHFAE LQEKFSSLQS EHKILHDQHC QMSAKMSQLQ SYVDMLKAEN SVLSTSLRNS
     QGDLVKEEMP GPREGRFLSL SFSCVTDSSS ITSLGESSFY KELLEHTGEA SLLNNLEGDV
     SANRSPAEEA SSSSLEEEVL TKTDIPPAPA RTIEELETLC QMYRQSLQKL EEKMESQGIM
     KNKEIEELEQ LLSCERKELD CLREQYLSEN EQWQQKLTSV TMEMESKLAA EKKQTEQLSL
     ELEVARLQLQ GLDLSSRSLL GADVEDVIRD GNDSCDIKES EENTSETRAR TPKDDIHQIG
     DKADQQDLSL EVEKITETGA VNLTGEWSRE QSPDTSHETP VEDKTLGCSE CVSELPPSGP
     NALVPMDVLE NQVTIQNLQL QVKETSDENL RLLHVIEERD KKVESLLNEL KELDSKLDLQ
     KVQLTTKVET CLELEKTVEE LKKEKSDLSE KLESFSCDNQ KLHQRVESLE GVSSNLEVGT
     EKSSHEIIED NVANVNNWRE RFFDAENELK RIKSEKSSIE LHALSVEADL ERVQTEKLYL
     EKDNENKQNV ITCLEEELSV VTSERNRLHG ELDTLSKENK ELDQASEKMK EKVLELESRQ
     GECLQHLDVV GAEVREKTQL LQTLSSEVSE LLEDKGHLQE QLQSLEKDSQ TLSLVKSELE
     NQIGQLSEEK ESLVKESESL QTKLNELEHE KLDVAKALEA ALMEKGEVAV RLSSTQEEVH
     QLRKGIEKLR VRIEADEKKQ LHALEKLKES ERKNDSLQDK VENLERELQM SEENQELVIL
     DAENCRAEAE TLKTQIELMT ESLKVLEGDL TTVRSEKENL MKELQEKQGQ VSELDTLVSS
     FKNLLEEKEQ EKIQMKEQSK AAVEMLQTEL KELNEEVAAL CDDQETWKAK EPSPDSAALG
     VQQLRTSIEK VKVLLEADEK KQLHTLGELK ESRHHVDLLK DRVENLEREL EISKEKQERV
     RLEAENSKAE VVTLKVKIEE MAQSLRDLEL DLGNIRSEKE NLTKELQKEQ GRVSELEVLN
     CSFENLLQEK EQEKVEMKEE SKIAVEMLQT QLKELNEKVA ALCNDQEIFK AKEQNLSSQV
     DSLEHERSQL LQGLDEAKSN YIILQSSVNG LVQEVEGGKQ KLEKKDEEIS ILKNQLQDQE
     QLLSKLSQVE GEQQLCKNQK IELGNLVVEL EQKIQGLQSK NDTLQDTLDM LQNSYKDLEK
     ELELAKMEKM SFVEQVNTMT AKETELQREM HEMVRERTEL KEGFTGEKQR LREELNLMSE
     EIKSSKGQLK ELMLENSELK KSLDCAHKDQ MEKHEKMREE IAGYHLRLQD AEKKHQALLL
     DTNKQYEMEI QTYQEKLTSK EECLSSQKAE MDLLKSSKEE LSNSLKATTE ILEELKKAKM
     DNLKHANQLK KENERAQGKI KLLIKSCKQL EAEKEMLQKE LSRLEAAQEK QKTGTVVDAN
     VDELMTEMKE LKETLEEKNK EADEYLEKYC SLLISHEKLE KDKEMLETQV ARLSSQQSKL
     NLPSSPLLNS VVPGSSPAPS VTEKKLPSGQ NKASGKRQRS SGIRENGEGT TPSTPETFSK
     KSRKAVKSGI HPAEDAEYAE FEPEGLPEVV KKGFADIPTG KTSPYVLRRT TMATRTSPRL
     AAQKLAPSPL SLDKENHAET SKPTAGGSRS QKVKAAQQSP ADSGSASREP STKSLSSCGL
     EYLDFVNWKR ENGLNGDLAE LKVLPPECV
//
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