ID A0A3Q2L3J1_HORSE Unreviewed; 914 AA.
AC A0A3Q2L3J1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DnaJ heat shock protein family (Hsp40) member C6 {ECO:0000313|Ensembl:ENSECAP00000032388.3};
GN Name=DNAJC6 {ECO:0000313|Ensembl:ENSECAP00000032388.3,
GN ECO:0000313|VGNC:VGNC:50829};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000032388.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000032388.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032388.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000032388.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032388.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005610579.1; XM_005610522.2.
DR AlphaFoldDB; A0A3Q2L3J1; -.
DR Ensembl; ENSECAT00000051356.3; ENSECAP00000032388.3; ENSECAG00000016430.4.
DR GeneID; 100069605; -.
DR VGNC; VGNC:50829; DNAJC6.
DR GeneTree; ENSGT00940000158755; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000016430; Expressed in prefrontal cortex and 20 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2L3J1; baseline.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd14563; PTP_auxilin_N; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR23172; AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED; 1.
DR PANTHER; PTHR23172:SF4; TYROSINE-PROTEIN PHOSPHATASE AUXILIN-RELATED; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 55..222
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 139..210
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 228..366
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 850..914
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 451..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 99700 MW; 351C038BDB0B05AC CRC64;
MKDSENKGAS SADMEPSYGG GLFDMVKGGA GRLFSNLKDN LKDTLKDTSS RVIQSVTSYT
KGDLDFTYVT SRIIVMSFPL DSVDIGFRNQ VDDIRSFLDS RHPDHYTVYN LSPKSYRTAK
FHSRVSECSW PIRQAPSLHN LFAVCRNMYN WLLQNPKNVC VVHCLDGRAA SSILVGAMFI
FCNLYSTPGP AVRLLYAKRP GIGLSPSHRR YLGYMCDLLA DKPYRPHFKP LTIKSITVSP
VPFFNKQRNG CRPYCDVLIG ETKIYTTCAD FERMKEYRVQ DGKIFIPLSI TVQGDVVVSM
YHLRSTIGSR LQAKVTNTQI FQLQFHTGFI PLDTTVLKFT KPELDACDVP EKYPQLFQVT
LDVELQPHDK VVDLTPPWEH YCTKDVNPSI LFSSHKEQQD TLVLGGQAPI DIPPDNPRHF
GQGGFFSSLC WQDQKSEKSF CEEDHAALVN QESEQSDDEL LTLSSPHGNA NGDKHHGAKK
PSKKQQEPAA PPPAEDVDLL GLEGAAVSKN FSPPAAPPSN SELLSDLFGG GGAAGPAQAG
QSGVEDVFHP SGPASTQSTP RRSAASASAS PTLRVGEGAT FDPFGAPSKS SGQDLLGSFL
NTSAASSDPF LQPTRSPSPT VHASSTPAVN IQPDVSGGWD WHTKPGGFGM GSKSAATSPT
GSSHGTPTHQ SKPQTLDPFA DLGTLGSSSF ASKPTTPTGL GGGFPPLSSP QKASPQPLGG
GWQQGGGYSW QQTPPSRPQP SMVHSSPQNR PNYNVSFSAV PGGQNERGKG AAHLEGKQKA
ADFEDLLSGQ GFNAHKDKKG PRTIAEMRKE EMAKEMDPEK LKILEWIEGK ERNIRALLST
MHTVLWAGET KWKPVGMADL VTPEQVKKVY RKAVLVVHPD KATGQPYEQY AKMIFMELND
AWSEFENQGQ KPLY
//
