ID A0A3Q2L8B1_HORSE Unreviewed; 1924 AA.
AC A0A3Q2L8B1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSECAP00000035422.3};
GN Name=DENND4C {ECO:0000313|Ensembl:ENSECAP00000035422.3,
GN ECO:0000313|VGNC:VGNC:17126};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000035422.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000035422.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035422.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000035422.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035422.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000034156.3; ENSECAP00000035422.3; ENSECAG00000000298.4.
DR VGNC; VGNC:17126; DENND4C.
DR GeneTree; ENSGT00940000158215; -.
DR Proteomes; UP000002281; Chromosome 23.
DR Bgee; ENSECAG00000000298; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 57..216
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 208..657
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 921..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1924 AA; 213477 MW; C654D390EEDE5078 CRC64;
MLAQGESSSA KGNIIATMIA DKGPRVTDYF VVAGLTDTSI LLDQEINRLD TKSTGPKAPI
TDIAVINKSA GETVPEGYTC VEATPSALQA NLNYGSLKSP ELFLCYKRGR NKPPLTDVGV
LYEGKERLIP GCEVIQATPY GRCANVNNSS TTSQRIFITY RRAPPVRPQN SLAVTDICVI
VTSKGETPPH TFCKVDKNLN CGMWGSSVFL CYKKSVPASN AIAYKAGLIF RYPEDDYESF
PLSESVPLFC LPMGATIECW DPQTKYPLPV FSTFVLTGSS AEKVYGAAIQ FYEPYSRELL
TEKQLLQLGL LTPVERKVVS KSINSNKCIC LLSHWPFFEA FRKFLMFIYK LSVSGPHPLP
IEKHISHFMQ NIPFPSPQRP RILVQLSVHD ALILSQPVST PLPLSGANFS TLLMNLGPEN
CATLLLFVLL ESKILLHSLR PAVLTGVAEA VVAMIFPFQW QCPYIPLCPL SLATVLSAPF
PFIVGVDSRY FDLHDPPQDV VCIDLDTNML YVSDEKKNMN WKQLPKKPCK SLLSTLKKLY
PQLSSVHRKT QEGSAIEMTP IEADFSWQKK MTQLEMEIQE AFLRFMASIL KGYRTYLRPI
TEAPSNKATA ADSLFDRQGF LKSRDRAYTK FYTLLSKTQI FIRFIEECSF VSDKDTGLAF
FDDCIEKLFP DKGIEKTDKV DFDLAEDTKL IELDDSQKSE HTVFIMPPEP PPDDGNDLSP
KYSYTCFPRL DLKLFDRPQE LKLCFSRHPT GNSIAKSPAL MAKRTKQEIK TAHKLAKRCY
TNPPQWAKCL FSHCYSLWFI CLPAYVRVSH PKVRALQQAY DVLIKMRKTD VDPLDEVCYR
VVMQLCGLWG HPVLAVRVLF EMKTAKIKPN AITYGYCNKV VLESPWPSST RSGIFLWTKV
RNVVRGLAQF RQPLKKTVQK SQVSSISGGQ SDQGYGSKDE LRKDDAEIHV PEEQIARELI
TKTKVQTEEV CDVSAVVAKH SQPRAEPQSP TEPPAWGSSI VKAPSGVFDI SGRKSSTGST
SNMLFSPEDP VEDAVFGEVT SLKNGDIGEK RQKHFPERSC SFSSESRAGM LLKKSSLDLN
SSEVAIMMGA DAKILTAALT CPKTSPLHIA RTHSFESVGC HLADTRTRVS ENAWDSEPRS
LVLEMLEESQ ELLEPVVDDN VAESTMTKDT YDSLQNDSDR NQSRDLKAGS KDLINKRSSL
CGVAKAVERE DVETGLDPLS LLATECIGEK TPDSEDKLFS PVIARNLADE IESYMNLKSP
LGSKSSSMEL HREGNRESGT ATAFSRPLER RSSLPLDHGP PAQDAPESEK SSPAVSRSKT
PTGRFKQQTP SRGQKERSTS LSALVRSSPH GSLGSVVNSL SGLKLDNILS GPKIDVLKSG
MKQAATVASK MWVAMASAYS YSDDEEEANR DYSFPAGLED HILGENISPN MSVSGLVPSE
LTQSNTSLGS SSSSGDVGRL HYSTGELPFP KGVKGQDFEK SDHGSSQNTS LSSIYQNCAM
EVLMSSCSQC RACGALVYDE EIMAGWTADD SNLNTTCPFC KSNFLPLLNI EFKDLRGSAS
FFLKPSTSGD SLQSGSIPLA SEPLEHKPVS SSVEPDLISF MDFPKHNQTI TEETNSAVES
SDEIRKASED VQTMKISPVP NSLSKRNVSL TRSHSVGGPL QNIDFSQRPF HGISTVSLPN
SLQEVVDPLG KRPNPPPVSV PYLSPLVLRK ELESLLENEG DQVIHTSSFI NQHPIIFWNL
VWYFRRLDLP SNLPGLILTS EHCNGGVQLP LSSLSQDSKL VYIQLLWDNI NLHQEPGEPL
YVSWRNLNSE KKLSLLSEEQ QATSTLVETI RQSIQRNDVL KPINLLSQQM KPDVKRQRSL
YREILFLSLV SLGRENIDIE AFDNEYRLAY SSLPSEILEK LPKIDAPPSV SMEWCRKCFG
APLI
//
