ID A0A3Q2LBJ9_HORSE Unreviewed; 719 AA.
AC A0A3Q2LBJ9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Platelet and endothelial cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSECAP00000037222.2};
GN Name=PECAM1 {ECO:0000313|Ensembl:ENSECAP00000037222.2,
GN ECO:0000313|VGNC:VGNC:21301};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000037222.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000037222.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037222.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000037222.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037222.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q2LBJ9; -.
DR Ensembl; ENSECAT00000056191.2; ENSECAP00000037222.2; ENSECAG00000006991.4.
DR VGNC; VGNC:21301; PECAM1.
DR GeneTree; ENSGT01070000253837; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000006991; Expressed in chorionic villus and 23 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR040878; IL-40-like_Ig.
DR PANTHER; PTHR11481:SF60; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11481; IMMUNOGLOBULIN FC RECEPTOR; 1.
DR Pfam; PF13895; Ig_2; 2.
DR Pfam; PF17736; Ig_C17orf99; 1.
DR SMART; SM00409; IG; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 583..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..107
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 217..295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 479..571
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 697..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 80211 MW; 233F3F4D9CDD359A CRC64;
MANLRVLRDL LSFTINSIYM KILPRDTVQN GENLTLQCIV DVSTTSRVKP KHSLLFYKDD
VLFYNVSSIE NTESYVIPQA RVYDAGIYKC SVILNNKQKT TAESQVLVKG VPRPRVTLDK
KETIEGGTVT VNCSVPEERA PIHFTIEKHD LDTKGFRQKR EKTSQKQNFV TLEFTVEEQD
RLLSFHCQAS IVSGNRVETS ESSRSELVTV TESFSMPKFN VSPQGKITEG EQLRIVCTIQ
VRHLAQFPEI IIQKDKVIVA HSNHGSEAVY SVMAMMEHNG NYTCKVEASR ISKVTSIMVN
ITELFSKPKL ESPTIRLDKG GSLDLWCSIP GAPTANFTIQ KGHTVVSQSQ NFTKIASKWD
SGTYTCTAGI GKVVKKSNTV QIAVCEMLSK PKIFRDSKSE VIKGQAIEVS CQSSDGTSPI
FYQLFKANNV LKSHNMSSNE PAVFKDNPTK DVEYYCIVDN CHSHTKMVSE VLRVKVIAPV
EEVKLSILLT EVVETGKPIV LRCSVNNASG PITYTFYREK EGKPFYQVIS NETQAIWHES
QASKEQEGQY YCTASNRANL AKKVPQSNAL TVRVFLSPWK KGLIAVVIIG VIIALLILGA
RCYFLKKAKA KQNPVAMPRL GAPLLNSNNE KMLSDPNTEA NRHYGYSEDV GNHAMKPINE
NKEPLTSDVE YTEVEVTSPE PHQGLGTKGT ETVYSEIRKA DPDFVENRYS RTEGSLDGT
//
