ID A0A3Q2LH88_HORSE Unreviewed; 1415 AA.
AC A0A3Q2LH88;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=CD109 molecule {ECO:0000313|Ensembl:ENSECAP00000040290.3};
GN Name=CD109 {ECO:0000313|VGNC:VGNC:16244};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000040290.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000040290.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000040290.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000040290.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000040290.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR Ensembl; ENSECAT00000057034.3; ENSECAP00000040290.3; ENSECAG00000023066.4.
DR VGNC; VGNC:16244; CD109.
DR GeneTree; ENSGT00940000155926; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000023066; Expressed in articular cartilage of joint and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2LH88; baseline.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF162; CD109 ANTIGEN; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1415
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040352373"
FT DOMAIN 468..599
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 693..784
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1311..1395
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1415 AA; 157963 MW; 80325E4B1E0DF590 CRC64;
MRGPRPLSAA QLVCVWTAAL AAGPGPRFLV TAPGIIRPGG NVTIGVELLE HSPPQVTVKA
ELVKKAANLT VSVLEAEGLF EKGSFKTLIL PSLPLNSADE IYELHVAGRA QDEILFSNST
RLSFETKRMT VFIQTDKSLY KPKQDVKFRI VTLFSDFKPC RTAVNILIKD PKSNLIQQWL
SEQSDLGVIS KTFRLSSHPI LGDWSIQVQV NDQMYYQSFQ VSEYVLPKFE VALQTPLYCS
LNSKSLNGTV IAKYTYGKPV KGDVTLTFLP LSFWGMKKNI TKKFKINGYA NFSFNDEEMK
KVMEFSDGLS EHVYLSSPGP VEILATVTES LTGISRNASS NVFFKQHDHI IEFFDYATVL
KPSLNFTATV KVTRSDGNQL TPEERRTNVV ITVTQRNYTV YWSRWNSRDQ EVEAVQIINY
TVPQNGIFKI EFPILDDSSE LQLKASFLNS VSSMAVHGMF MSPSKTYIQL KTRDENIKVG
SPFELVVSGN KQLKELSYMV VSRGQLVAVG KQNSTAFSLT PENSWAPKAC IIVYYIEDDG
EIINDVLKIP VHLVFKNKIN LFWSKANAEP SEKVSLRVSV TQPDSVVGIV AVDKSVNLMN
ASNDITMENV VHELELYNTG YYLGMFMNSF AVFQECGLWV LTDAHLVKDS IDGVYDSVES
AERFVEESEA YMVDLRDFAL GGRPHVRRHF PETWLWLDAN MGSRMDEEFE VTVPDSITSW
VATAFVISED LGLGLTTTPV ELQAFQPFFI FLNLPYSVIR GEEFALEVTI FNYLKDVTEV
KVIIEKSDKF DILMASNEIN ATGHQQTILV PSEDGATVLF PIKPIRLGEI PITVTAVSLA
ASDAVTQKIL VKAEGIEKSY SQSILLDLTD NKLQTTLKTL SFSFPPDTVS GSARVQVTAI
GDILGSSING LASLIRMPYG CGEQNMINFA PNIYVLDYLT KKKQLTENLK EKALSFMRQG
YQRELLYQRE DGSFSAFGKD DPSGSTWLSA FVLRCFLEAD PYIDIDQNVL HRTYTWLKGR
QKSSGEFWEP GRVIHSELQG GSTSPVTLTA YIVTSLLGYK KYQPNIDVQE SINFLESEFN
RGISDNYTLA LITHALSSVR SPKAKEALDM LTWRAEREGD TQFWVSSVSR LSESWQPSSL
DIEVAAYALL SHFLQGQLSA GVPVMRWLSR QRNRLGGFVS TQDTIVALKA LSEFAALMNT
ERTNIQVTVM GPTSPSPIKF LIDTQNRFLL QTAELAAVQP TTVNISAKGL GFAVCQLNII
YNVKDSGSSR SQKSIQNQEA FDLDVAVKDN KDDLNHLNLN VCTRFLGPAR SGMALMEVNL
LSGFMVPSDA IPLSETLKKV EHEHGKLNLY LDSVNETLFC VDIPAVRNFK VSNTQDALVS
IVDYYEPRRQ AVRSYNSEVK LSSCDLCGDD HSCRP
//
