ID A0A3Q2LJD4_HORSE Unreviewed; 795 AA.
AC A0A3Q2LJD4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=EMAP like 1 {ECO:0000313|Ensembl:ENSECAP00000041368.2};
GN Name=EML1 {ECO:0000313|Ensembl:ENSECAP00000041368.2,
GN ECO:0000313|VGNC:VGNC:17564};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000041368.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000041368.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041368.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000041368.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041368.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR AlphaFoldDB; A0A3Q2LJD4; -.
DR Ensembl; ENSECAT00000050247.2; ENSECAP00000041368.2; ENSECAG00000019766.4.
DR VGNC; VGNC:17564; EML1.
DR GeneTree; ENSGT00940000153887; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000019766; Expressed in oviduct epithelium and 22 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR CDD; cd21947; TD_EMAP1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF22; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 168..239
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 519..551
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 648..679
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 760..795
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 56..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..51
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 71..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 87514 MW; 23060DF4BCAC59AB CRC64;
MDDSASAASS MEVTDRIASL EQRVQMQEDD IQLLKSALAD VVRRLNITEE QQAVLNRKGP
TKARPLVQTL PLRPTVNNGT VLPKRPSGSL PSPSGARKET AVHAATKSTI KRTSSSERVS
PGGRRESYGD SKGNRNRAGS TSSSSSGKKN SESKPKEPVF SAEEGYVKMF LRGRPVTMYM
PKEQVDSYSL EAKAELPAKR LKLEWVYGYR GRDCRNNLYL LPTGETVYFI ASVVVLYNVE
EQLQRHYAGH NDDVKCLAVH PDRITIATGQ VAGTSKDGKQ LPPHVRIWDS VTLNTLHVIG
IGFFDRAVTC IAFSKSNGGS NLCAVDDSND HVLSVWDWQK EERLADVKCS NEAVFAADFH
PTDTNIIVTC GKSHLYFWTL EGNSLIKKQG LFEKQEKPKF VLCVTFSENG DTITGDSSGN
ILVWGKGTNR ISYAVQGAHE GGIFALCMLR DGTLVSGGGK DRKLISWNGN YQKLHKTEIP
EQFGPIRTVA EGKGDVILIG TTRNFVLQGT LAGDFAPITQ GHTDELWGLA IHASKPQFLT
CGHDRHATLW DAVGHRPVWD KIIEDPAQSS GFHPSGSVVA VGTLTGRWFV FDTETKDLVT
VHTDGNEQLS VMRYSPDGNF LAIGSHDNCI YIYGVSDNGR KYTRVGKCSG HSSFITHLDW
SVNSQFLVSN SGDYEILYWV PSACKQVVSV ETTRDIEWAS HTCTLGFHVF GVWPEGSDGT
DINAVCRAHE KKVLCTGDDF GKVHLFSYPC SQFRAPSHVY SGHSSHVTNV DFLCDDSHLI
STGGKDTSIM QWRVI
//
