ID A0A3Q2LSV0_HORSE Unreviewed; 276 AA.
AC A0A3Q2LSV0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=N-acetylneuraminic acid phosphatase {ECO:0000313|Ensembl:ENSECAP00000045784.3};
GN Name=NANP {ECO:0000313|Ensembl:ENSECAP00000045784.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045784.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045784.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045784.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045784.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045784.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR AlphaFoldDB; A0A3Q2LSV0; -.
DR STRING; 9796.ENSECAP00000045784; -.
DR PaxDb; 9796-ENSECAP00000045784; -.
DR Ensembl; ENSECAT00000063684.3; ENSECAP00000045784.3; ENSECAG00000039564.3.
DR GeneTree; ENSGT00390000003094; -.
DR InParanoid; A0A3Q2LSV0; -.
DR OMA; PQETHDT; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000039564; Expressed in bone marrow and 23 other cell types or tissues.
DR GO; GO:0050124; F:N-acylneuraminate-9-phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR GO; GO:0046380; P:N-acetylneuraminate biosynthetic process; IBA:GO_Central.
DR CDD; cd04305; HAD_Neu5Ac-Pase_like; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 1.20.120.710; Haloacid dehalogenase hydrolase-like domain; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR011950; HAD-SF_hydro_IA_CTE7.
DR InterPro; IPR023214; HAD_sf.
DR NCBIfam; TIGR02253; CTE7; 1.
DR NCBIfam; TIGR01549; HAD-SF-IA-v1; 1.
DR PANTHER; PTHR46470; N-ACYLNEURAMINATE-9-PHOSPHATASE; 1.
DR PANTHER; PTHR46470:SF2; N-ACYLNEURAMINATE-9-PHOSPHATASE; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR SFLD; SFLDG01135; C1.5.6:_HAD__Beta-PGM__Phospha; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
SQ SEQUENCE 276 AA; 30978 MW; 9E079ACC61378CD6 CRC64;
MGLSRVRAVF FDLDNTLIDT AGASRKGMLE ACPSVSLLKR KPSTEIWGFS VNKAEKIYAF
VIKLLQSKYH YKEEAEIICD KVQVKLSKEC FHPSNTCITD LRTSHWEEAI QETKGGTANR
KLAEECYCLW KSTRLQHMTL AEDVKAMLTE LRKEVRLLLL TNGDRQTQRE KIEACACQSY
FDAIVVGGEQ KEEKPAPSIF YYCCDLLGVQ PGDCVMIGDT LETDIQGGIN AGLKATVWIN
KNGIVPLKSY PMPHYIVSSV LELPALLQSI DCKVNM
//
