ID A0A3Q2LUJ9_HORSE Unreviewed; 555 AA.
AC A0A3Q2LUJ9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Thioredoxin domain-containing protein {ECO:0000259|PROSITE:PS51352};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000046624.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000046624.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000046624.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000046624.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000046624.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347}.
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DR AlphaFoldDB; A0A3Q2LUJ9; -.
DR STRING; 9796.ENSECAP00000046624; -.
DR PaxDb; 9796-ENSECAP00000046624; -.
DR Ensembl; ENSECAT00000056697.3; ENSECAP00000046624.3; ENSECAG00000010735.4.
DR GeneTree; ENSGT00940000160939; -.
DR InParanoid; A0A3Q2LUJ9; -.
DR OMA; YKMTPQT; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000010735; Expressed in leukocyte and 4 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd02961; PDI_a_family; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR CDD; cd02982; PDI_b'_family; 1.
DR CDD; cd02981; PDI_b_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF58; PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 348..498
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 494..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 63896 MW; 1738391B271A93B3 CRC64;
AGQLWMSLLL VVDVKEASIN TSQPLHILVE RNLLVLTPAG LTHRLNQTRF LMVLFYIPSS
KQSRNMAEEL GRAAEIMGKG KNGVGFGKVD ITIEKELQKE FDIKKTPDLK LFFEGNRSEP
ISCKGVVEST ALVVWLRRQI SQKAFLFTDT QQVVEFVKSR PLVIVGFFQD LEEEVAELFY
DVIKDFPELT FGVTSISNAI GRFHVPLDSV LVFKKGKIVK RQELIYDSTN KQVLSQVIKE
HLTDFVIEYN IENKDLIYEL NILNHMLLFI SKSSKSFGTI MQHCKLALKE FQNKILFILV
DADEPRNRHV FKHFRIAEVN IPSVQILNLS SDARYKMPSE EITYKNLKKF GHSFLNKSAK
NHQSSEEIPK YWDQGPVKQL VGKNFNVVVF DKERDVFVMF YAPWSEKCRA LFPVLEELGR
KYQNHSTVTI AKIDITANDI QLMNLDRYPF FRLFPTDSQQ AVPYKGEHTM KGLEDEGELL
SIEQSEVIEE EVLAEEEEVP FMQKELPEQK LPELENGTKL EEPAGQKETA QKEEKVAKPK
GPPRQEKKPR VKEEL
//
