ID A0A3Q2TTF7_CHICK Unreviewed; 503 AA.
AC A0A3Q2TTF7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Scavenger receptor class B member 1 {ECO:0000256|ARBA:ARBA00040821};
DE AltName: Full=SR-BI {ECO:0000256|ARBA:ARBA00042244};
GN Name=SCARB1 {ECO:0000313|Ensembl:ENSGALP00010030016.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010030016.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010030016.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010030016.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, caveola
CC {ECO:0000256|ARBA:ARBA00004189}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004189}.
CC -!- SIMILARITY: Belongs to the CD36 family.
CC {ECO:0000256|ARBA:ARBA00010532}.
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DR RefSeq; XP_415106.2; XM_415106.4.
DR AlphaFoldDB; A0A3Q2TTF7; -.
DR SMR; A0A3Q2TTF7; -.
DR STRING; 9031.ENSGALP00000065433; -.
DR PaxDb; 9031-ENSGALP00000004761; -.
DR Ensembl; ENSGALT00010050825.1; ENSGALP00010030016.1; ENSGALG00010021011.1.
DR GeneID; 416814; -.
DR CTD; 949; -.
DR VEuPathDB; HostDB:geneid_416814; -.
DR GeneTree; ENSGT00940000153372; -.
DR InParanoid; A0A3Q2TTF7; -.
DR OMA; DENYWIN; -.
DR OrthoDB; 315994at2759; -.
DR Reactome; R-GGA-3000471; Scavenging by Class B Receptors.
DR Reactome; R-GGA-8964011; HDL clearance.
DR Proteomes; UP000000539; Chromosome 15.
DR Bgee; ENSGALG00000046226; Expressed in liver and 11 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2TTF7; baseline and differential.
DR GO; GO:0005901; C:caveola; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR GO; GO:0034186; F:apolipoprotein A-I binding; IEA:Ensembl.
DR GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0070506; F:high-density lipoprotein particle receptor activity; IEA:Ensembl.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR GO; GO:0001875; F:lipopolysaccharide immune receptor activity; IEA:Ensembl.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IBA:GO_Central.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR GO; GO:0044406; P:adhesion of symbiont to host; IEA:Ensembl.
DR GO; GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:0046867; P:carotenoid transport; IEA:Ensembl.
DR GO; GO:0006707; P:cholesterol catabolic process; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0070508; P:cholesterol import; IBA:GO_Central.
DR GO; GO:0032497; P:detection of lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0098856; P:intestinal lipid absorption; IEA:Ensembl.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:Ensembl.
DR GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0015914; P:phospholipid transport; IEA:Ensembl.
DR GO; GO:0034381; P:plasma lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0010886; P:positive regulation of cholesterol storage; IEA:Ensembl.
DR GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Ensembl.
DR GO; GO:0043654; P:recognition of apoptotic cell; IBA:GO_Central.
DR GO; GO:0010899; P:regulation of phosphatidylcholine catabolic process; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
DR GO; GO:0035461; P:vitamin transmembrane transport; IEA:Ensembl.
DR InterPro; IPR005428; CD36/SCARB1/SNMP1.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923:SF96; SCAVENGER RECEPTOR CLASS B MEMBER 1; 1.
DR PANTHER; PTHR11923; SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01610; CD36ANTIGEN.
DR PRINTS; PR01609; CD36FAMILY.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2TTF7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 503 AA; 55918 MW; CAE4BB8470D97905 CRC64;
MVAAGRRVAV GLGAVGAVCL LLGGCLLLAG PAIVKEQVLK NVRIDPSSIS FNMWRDIPVP
FYLTVNLFEV QNPQEVLQGA KPKVNQRGPY VYREFKYKTN ITFHDNDTVS YLEYRQLFFR
PDLSNGTEDE YIVMPNILML GAAVMMENLP SFVKLLLSGA LAGLKQEAFI NRTVGEILWG
YEDPLLDTIN ALVPGLIPYK GKFGIFIEFN NTNSGLFTVN TGMKNISQVH MVDSWNGLKK
VNYWRTNECN MINGTAGEMW PPYMSPTSLE FYSPDACRSM TLVYEQSGKF KGVPTYRFVA
PKTLFANGTD YPPNEGFCPC RQSGIQNVSS CRLNAPMFIS HPHFYNADPS LVDAVEGLHP
SREEHALFLD VHPVTGIPMN CSIKLQLNQY MKQVSGILQT GKIQPVVMPL LWFAESGYID
GSVLSQFYTN LVLIPSILDY LQYIFLGLSV PLIISAALVM MSQKSSKEKH PHDPTTQSPP
PQPSETTPLL QDTGTQSQDT AEA
//
