ID A0A3Q2U2L2_CHICK Unreviewed; 797 AA.
AC A0A3Q2U2L2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|ARBA:ARBA00017947, ECO:0000256|PIRNR:PIRNR007949};
GN Name=VPS16 {ECO:0000313|Ensembl:ENSGALP00010008398.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010008398.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010008398.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010008398.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Late endosome membrane {ECO:0000256|PIRNR:PIRNR007949}; Peripheral
CC membrane protein {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Note=Cytoplasmic, peripheral membrane
CC protein associated with late endosomes/lysosomes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR AlphaFoldDB; A0A3Q2U2L2; -.
DR Ensembl; ENSGALT00010014304.1; ENSGALP00010008398.1; ENSGALG00010005978.1.
DR VEuPathDB; HostDB:geneid_426571; -.
DR GeneTree; ENSGT00390000003896; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000034510; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2U2L2; baseline and differential.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 2.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|PIRNR:PIRNR007949};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007949};
KW Membrane {ECO:0000256|PIRNR:PIRNR007949};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 207..379
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 476..793
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 797 AA; 91360 MW; 6B295070DEBC01F5 CRC64;
MDCYTANWNP LGEEAFYRKF ELYTMEWGLK EDLRDCLVAA APYGGPIALL KNNARKEKSP
STRPLLEIYS ASGLLLASIP WKSGQLVQLG WTASEDLLCI QEDGTVLIYN LFCEFKRHFS
MGNEVLQNHV LEAKVFHTEY GTGVAILTGA HRFSLTTNID DLKLRRMPEV PGLQKPPSCW
AVLTQDRVTI VLLAVGQDLY LLDNTSCSVV DKLCEFNSTI RSPPKQMVWC TRPRSRQRAV
VVAWDRQLMV AGDSTECIRF VLDEDSYLVP EPDGVRILSR TSHEFLHEIP EASQEIFKIA
SMAPGALLLE AQKEYEKESQ KADEYLREIK DQKLLPEAVS QCIEAAGYEH EPETQKSLLR
AASFGKCFID KFPPESFVRM CQDLRVLNSI RDYQIGIPLT FTQYKRLTVE VLLDRLVLRR
LYPLAIRICE YLRLPEIQGV SRILAHWACY KVQQKDKSDE EVAYAINQKL GDTPGISYSE
IAARAYDCGR TELAIKLLEY EPRSGEQVPL LLKMKRSKLA LSKAIESGDT DLVYTVVLHL
KNELNRGTFF MTLQNQPVAL SLYRQFCKHQ ERETLKDLYN QDDNHQELGN FHVHSSYSEK
RIEGRVGALQ NAVDEYYKAK NEFAAKATED QIKLLRLQRH LQEDFDKPYL DLSLHNTVST
LIQDGHHKKA EQLYRDFKIP DKRYWWLKIS ALATRGDWEE MEKFSKSKKS PIGYLPFVEI
AVKHHNRYEA KKYAPRVTPE QRVKAFILVG DLEQAADAAI EHKNEAEMNL VLSKCSAATD
SAVMEKLNRA RAQLLKK
//
