ID   A0A3Q2U6L6_CHICK        Unreviewed;      1112 AA.
AC   A0A3Q2U6L6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=GEM interacting protein {ECO:0000313|Ensembl:ENSGALP00010004804.1};
GN   Name=GMIP {ECO:0000313|Ensembl:ENSGALP00010004804.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010004804.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010004804.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010004804.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_004950876.1; XM_004950819.2.
DR   AlphaFoldDB; A0A3Q2U6L6; -.
DR   SMR; A0A3Q2U6L6; -.
DR   STRING; 9031.ENSGALP00000070125; -.
DR   Ensembl; ENSGALT00010008020.1; ENSGALP00010004804.1; ENSGALG00010003439.1.
DR   GeneID; 426010; -.
DR   KEGG; gga:426010; -.
DR   CTD; 51291; -.
DR   VEuPathDB; HostDB:geneid_426010; -.
DR   GeneTree; ENSGT00950000183110; -.
DR   InParanoid; A0A3Q2U6L6; -.
DR   OMA; QYMLGLD; -.
DR   OrthoDB; 5395569at2759; -.
DR   Reactome; R-GGA-8980692; RHOA GTPase cycle.
DR   Reactome; R-GGA-9013148; CDC42 GTPase cycle.
DR   Reactome; R-GGA-9013149; RAC1 GTPase cycle.
DR   Proteomes; UP000000539; Chromosome 30.
DR   Bgee; ENSGALG00000029354; Expressed in spleen and 10 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR   CDD; cd20816; C1_GMIP-like; 1.
DR   CDD; cd04408; RhoGAP_GMIP; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR15228:SF16; GEM-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   1112 AA;  124103 MW;  1904DE8D8F45CAE1 CRC64;
     MNGLGSRDDA RVADGFPAGF LPPEHNSHLG IPAASWAPSH CPTPEHRAGE VLRVTQHLKS
     IDGKFQCLRE LFQKGEDFSG PVKAKLSDLL HSIFSFLNTY PAVTGDAIHL AIATLIANIN
     GLDHQERAPE NKKRYSEIFR SLDAIEISIG NAAVDMFIGD ADGTGDAELS TEREIIVPSE
     DLSKSKSSLE RQMQGDLTVE EADEMLIKCE GGIDAALEYA KMWCKYVKEL LSWIEKRLNY
     ETEFAKGIMK IAESGRNAII HQSNMPLRML YVMVLENDIK IGNAASETVG LLQQKEFYQP
     LSAKKNEIEK WRKEFKDQWT KEQKRMNESL SLLRKARLQY IQRCEEMEKA KQLSAKAEDE
     YQNSAIISPS SAIKHLEKRR RSCEEAQAKV QEAEALYRMC IGDANFRRQE LEKVRARIVS
     HIRKLIYQGD EVLTWVTLRM FKQRQTQSEQ IPVGYQHLSE VCKPYRVGEK YLEFIQALQK
     KDIPMEHFEF EPLSSGGQRS PPSNKKKTPL HYTGCSKDGS TPEDTPRRQF SPNGEQSVNK
     SLCSDTESLS GSCESRSLDS PSSSPGNSTR KLLKASSTGT MSSSDDFEER DSLQTSENEN
     GTSQQQFRNA LLSSAAQTHR LRKLRGPTKC RECDTFMVNG FECEECYLTC HKKCLENLLI
     TCGHKKLPNR VPLFGIDFTQ VPRDFPEEVP FIVVKCTSEI EARALGVQGI YRISGSKARV
     EKLCQAFENG RSLVELSEHS PHDITGVLKH FLKELSGPIL LYQLYDNLIA LAKELQKAGE
     EKVDCTSFPS DPIQSMKDLL SKLPGSNYNT LRHLIAHLYR VAEKYEENKM SPNNLGIVFG
     PTLIRPGSGS DVSMSCLVDS GYQAQIVEFL IQNYERVFGM EDLPSSLSLG CENPLQEAST
     EKDEEHQSPN TAQNVTLENP SSKHSSSVDD VSDISSSGEA MDGFMLESAH SSEGGEVNAS
     VGSELEDAEE KADSDSEPVF GTQPRGHFSR QPVKYVRAQP KTRPNIPKPS SLPLRATTSP
     SMATDSGAEG SPIDSTCMGK EILEERTRSR NSSPDMSALR HKGKQHKHFQ ITEETARIIS
     KFKADEVSAA PELSSGEKAV KFGPEIIPEK IL
//