ID A0A3Q2UKZ9_CHICK Unreviewed; 915 AA.
AC A0A3Q2UKZ9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Solute carrier family 8 member A3 {ECO:0000313|Ensembl:ENSGALP00010031085.1};
GN Name=COX16 {ECO:0000313|Ensembl:ENSGALP00010031085.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010031085.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010031085.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010031085.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR RefSeq; XP_015142768.1; XM_015287282.1.
DR AlphaFoldDB; A0A3Q2UKZ9; -.
DR Ensembl; ENSGALT00010052073.1; ENSGALP00010031085.1; ENSGALG00010021473.1.
DR VEuPathDB; HostDB:geneid_395759; -.
DR GeneTree; ENSGT00940000157547; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000009400; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2UKZ9; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF7; SODIUM_CALCIUM EXCHANGER 3; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 384..484
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 513..613
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 915 AA; 101645 MW; 3CB11D8FF29D297D CRC64;
MAWLSLQPLT SAFLHFGLVT FVLFLHGLQV DAGLTGDSTS SVQNSSCSGS FDCKEGVILP
IWYPENPSLG DKIARVIVYF VALIYMFLGV SIIADRFMAS IEVITSQEKE ITIKKPNGET
TTTTIRIWNE TVSNLTLMAL GSSAPEILLS LIEVCGHGFV AGDLGPSTIV GSAAFNMFII
IAICVYVIPD GETRKIKHLR VFFVTAAWSI FAYIWLYMIL AVFSPGVVQV WEGLLTLFFF
PLCVLLAWIA DRRLLFYKYM HKKYRTDKHR GIIIESEGDH PKGIEMDGKM MNSHFLDGNL
VTVEGKEVDE SRKEMIRILK DLKQKHPEKD LDQLVEMANY YALSHQQKSR AFYRIQATRM
MTGAGNILKK HAAEQAKKST SLHEVRPDEP EEFISKIYFD PCSYQCLENC GAVLLTVVRK
GGDVSKTIYV DYKTEDGSAN AGADYEFTEG TVVLKSGETQ KDFAVGIIDD DIFEEDEHFF
VRLSNLRVVD NEEPPELGNS PYPKAILASP CVATVTILDD DHAGIFTFEC DVIHVSESIG
VMEVKVLRTS GARGTVIVPF RTVEGTAKGG GEDFEDAYGE LEFKNDETVK TVRVKIVDEE
EYERQENFFI ALGEPKWMER GISEVAERKL TVEEEEAKRI AEMGKPILGE HPKLEVIIEE
SYEFKSTVDK LIKKTNLALV VGTHSWRDQF LEAITVSAAG DEDEDESGEE RLPSCFDYVM
HFLTVFWKVL FACVPPTEYC NGWACFVVSI LIIGMLTAVI GDLASHFGCT IGLKDSVTAV
VFVAFGTSVP DTFASKAAAI QDVYADASIT NVTGSNAVNV FLGIGLAWSV AAIYWASQGQ
EFQVSAGTLA FSVTLFTIFA FICISVLLYR RRPHLGGELG GPRGCKLATT LLFVSLWLLY
ILFATLEAYC YIKGF
//