ID A0A3Q2UST4_HAPBU Unreviewed; 1315 AA.
AC A0A3Q2UST4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSHBUP00000000400.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000000400.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000000400.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR Ensembl; ENSHBUT00000015547.1; ENSHBUP00000000400.1; ENSHBUG00000000798.1.
DR GeneTree; ENSGT00950000183214; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF18; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 273..348
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 434..508
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 549..624
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 80..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1060
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 146345 MW; E0E7DABE3F7AE363 CRC64;
MKVTVCFGRT RVVVPCGDGN VKVQSLIEQA AMRYKKAIAK DPSYWVQVNR LEHGDGGILD
QDDMLCDVVD DKDRLVAIYE EQDPHNGGDG TSASSTGTQS PEPFASEMNS ASAFQPYQAS
VIEVTPSALL SNMSLNVRRS SDPALAGFPP GEAPVAPEEP SRKNPTRWST TPGFQKPNHK
RNPSNETGSL EQKGRGAHAY RSLPRDASGW STQFQREMTR SSLSANHPMV DRWLDRQEQD
EEEEQRRHER RIERTEPVGR ADSSLEHSPV SMLKPVEVSN EGGPLGIHVV PFSSHDIRTQ
GLLVKRLEPG GKAEQERLFQ ENDCIVRINQ GDIRNLRFEQ AQNIFKQAMR SQVILFHVVP
AAMKKQYELL SAQKELSSPP QLNRVRFSQE SQQPADRSSL TGPTPSAPSP SLQRRISTNA
PRTIDLKNKG RRFNVQLKKG PEGLGFSITS RDVPIGGSAP IYVKNILPQG AAIQDGRLKA
GDRLLEVSGV DLNGKSQEEV VALLRATPMG GTVNLLVIRP EDSLLPREVQ EKDDIVLTPD
GTQEFMTFEI PLNDSGSAGL GVSVKGNRSK ENHEDLGIFV KSIINGGAAS KDGRLHVNDQ
LIAVNGESLL EKTNQEAMET LRKSMSVEGN KRGMIQLIVA RRVAMSSEEV PGSPSFLEHP
LNSILESHER RISDSLYETT EGPDSVSTPR ANTIGRIGRS QLSPTVNMPQ DDIVMIEDDR
PPLLPSHLSD QSSSSSHDDM GFVGENPVPW IHDSKLPDSA ISLSPDADPG TSFQREGYGR
QSMSEKRTKQ YENPAHLEII KSRKSKSMDL GSAEQQVGPS LGLKKSSSLE SLQTAVAGTV
QNGEINVRRS RSRIVRSRGC NESFRAAIDK SYEKPAVTAP EEENSVDTCE LDDDTSSRSG
QESMSTSGDL TSGPWLNGRD DRQKDQEKSG VKEKKKPERE KEKDKDKNKS KKGVLKGLFR
FGKNRKDERL DDKMERRSST KSKAEDMQAS EEETQQMRLE QERIQAKTRE LREKQAKERE
YAEIQDVVSR TFSSDEDHTY AGIGSLCSSI DSSTIDPYSH PYHLPQSPLN PHPPSLNLQD
NGPPLEALYA QVNKPRNGRP AAPDSSQMAP SNHDRIQRLR NEFQQAKQED DVEDHQHTYS
FNQSWQDQPP PPETGTSSGR HSVTVETQVQ KQQQEDRDDF PQAQRQYNSL PRQPRKNNSA
ASQDSWDKMY MPAEGFQPSK ENPRYSGGQG SRNGYLGTPS INARVFLETQ ELLRQEERRR
EQEASKTRPP PAQETPTRAL SKPKGPYRQD VPPSPSQIAK LSRHQSSVKG RLFYS
//
