ID A0A3Q2UT29_HAPBU Unreviewed; 459 AA.
AC A0A3Q2UT29;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=N-lysine methyltransferase SETD6 {ECO:0000256|ARBA:ARBA00016973, ECO:0000256|PIRNR:PIRNR011771};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000000572.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000000572.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Protein-lysine N-methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR011771}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR011771}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC {ECO:0000256|PIRNR:PIRNR011771}.
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DR RefSeq; XP_005945123.1; XM_005945061.2.
DR AlphaFoldDB; A0A3Q2UT29; -.
DR STRING; 8153.ENSHBUP00000000572; -.
DR Ensembl; ENSHBUT00000015248.1; ENSHBUP00000000572.1; ENSHBUG00000001755.1.
DR GeneID; 102308875; -.
DR CTD; 79918; -.
DR GeneTree; ENSGT00940000153577; -.
DR OMA; RVDWWLE; -.
DR OrthoDB; 51002at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19178; SET_SETD6; 1.
DR Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR011383; N-lys_methylase_SETD6.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044430; SETD6_SET.
DR PANTHER; PTHR13271:SF131; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR Pfam; PF00856; SET; 1.
DR PIRSF; PIRSF011771; RMS1_SET; 1.
DR SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR011771};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR011771};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR011771};
KW Transferase {ECO:0000256|PIRNR:PIRNR011771}.
FT DOMAIN 35..263
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 459 AA; 51771 MW; D8B36C4C6A32FD50 CRC64;
MAARAKRAKV EDGSELSPLQ SFLQWCDGVG LELSSKVCVS KEGTVAEYGM LAKDDIEDGE
VLFTIPRSAL LHQGTTKVST LLEKEQSTLQ SSSGWVPLLL ALLYEYTSSQ SHWKAYLSLW
TDFKTLDHPM FWSKEERGSL LKGTGVPEAV DRDLANIQRE YTDVVLPFMT RHPDLWNPGT
HTLDLYTQLV AFVMAYSFQE PQDEEDDDED EEKPPNPPVM VPMADMLNHV SNHNANLEFT
QDSLKMVCVR PIHKGQEVFN TYGQMANWQL LHMYGFTEPC SSNSNDTADI PVAKLYEAAA
RGAQSDLDRQ LVEEQWGVLC QMTEEEAAFV FGKQGCLTDT ELYTALKVLC MSKEELSEFK
DNEGWEEDDE DDEKISLALS NEGLSELKAS WKQLIYEAAH LTLRSYGDGE DEEKVMDVDR
ALMEDKAALA GLSCRQWKAL QVRYGQKSIL HGLMELTKS
//