ID A0A3Q2UU21_HAPBU Unreviewed; 884 AA.
AC A0A3Q2UU21;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Calcium/calmodulin dependent serine protein kinase {ECO:0000313|Ensembl:ENSHBUP00000001000.1};
GN Name=CASK {ECO:0000313|Ensembl:ENSHBUP00000001000.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000001000.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000001000.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q2UU21; -.
DR Ensembl; ENSHBUT00000014527.1; ENSHBUP00000001000.1; ENSHBUG00000002196.1.
DR GeneTree; ENSGT00940000155600; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12081; SH3_CASK; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR035473; CASK_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF40; PERIPHERAL PLASMA MEMBRANE PROTEIN CASK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..209
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 276..331
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 347..404
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 439..520
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 575..645
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 697..869
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 522..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 100342 MW; 90BEABF72B85DE49 CRC64;
MLKHPHIVEL LETYSSDGML YMVFEFMDGA DLCFEIVKRA DAGFVYSEAV ASHYMRQILE
ALRYCHDNNV IHRDVKPHCV LLASKENSAP VKLGGFGVAI QLGESGLVAG GRVGTPHFMA
PEVVKREPYG KPVDVWGCGV ILFILLSGCL PFYGTKERLF EAICKGKYKM NPRQWNHISE
SAKDLVRRML MLDPAERITV YEALNHPWLK ERDRYAYKIH LPETVEQLRK FNARRKLKGA
VLAAVSSHKF NSFYGDPPEE LQDFSDDPTS SGLLAAERAV SQVLDSLEEI HALTDCSEKD
LDFLHSVFQD QHLHTLLDLY DKINTKSSPQ IRNPPSDAVQ RAKEISSQDG ACGALKLLED
VLEEISCYPE KHEAKELRRI VTQPHFMALL QAHDVVAHEV YSDEALRVTP PPTSPFLNGD
SPESANGDMD LENVTRVRLV QFQKNTDEPM GITLKMNESN HCIVARIMHG GMIHRQGTLH
VGDEIREING ISVANQTVEQ LQKMLREMRG SITFKIVPSY RTQGSSCENE SPTTSRQSPA
NGHSSINSSI LDLPSTIQPK GRQIVSRPPI KDKMSVKIYV RAQFEYDPSK DELIPCKEAG
IRFRVGDIIQ IISKDDHNWW QGKLENTKNG TAGLIPSPEL QEWRVACIAM EKTKQEQQAS
CTWFGKKKKQ YKDKYLAKHN ADLVTYEEVV KLPAFKRKTL VLLGAHGVGR RHIKNTLITK
LPDRFAYPIP HTTRPPKKDE ENGKNYYFVS HDQMMQDISN NEYLEYGSHE DAMYGTRLET
IRKIHQQGLI AILDVEPQAL KVLRTAEFAP YVVFIAAPTI TPGINEDESL QRLQKESEIL
QKTYAHYFDQ TIINNEIDET IRHLEEAIDL VCTTSQWVPV SWVY
//