ID A0A3Q2UVH5_HAPBU Unreviewed; 633 AA.
AC A0A3Q2UVH5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DDX5 {ECO:0000313|Ensembl:ENSHBUP00000001694.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000001694.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000001694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|RuleBase:RU000492}.
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DR RefSeq; XP_005934556.1; XM_005934494.1.
DR AlphaFoldDB; A0A3Q2UVH5; -.
DR STRING; 8153.ENSHBUP00000001694; -.
DR Ensembl; ENSHBUT00000013361.1; ENSHBUP00000001694.1; ENSHBUG00000002856.1.
DR GeneID; 102308726; -.
DR GeneTree; ENSGT00940000154705; -.
DR OMA; TRVPSIM; -.
DR OrthoDB; 5477821at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF90; ATP-DEPENDENT RNA HELICASE DDX5-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 98..126
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 129..304
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 332..479
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 98..126
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..633
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 70421 MW; EFCDA5CD04A67823 CRC64;
MPGFSDRDRG RDRGYGGGPP RFGGGGGGNR GGPPPGKFGN PGERLRKKHW NLDELPKFQK
NFYQEHPDVT RRPLQEVEQY RRSKEVTVKG RDCPKPIVKF HEAAFPSYVM DVIVKQNWTE
PTPIQSQGWP VALSGKDMVG IAQTGSGKTL AYLLPAIVHI QHQPFLEHGD GPICLVLAPT
RELAQQVQQV AAEYGRASRL KSTCIYGGAP KGPQIRDLER GVEICIATPG RLIDFLECGK
TNLRRCTYLV LDEADRMLDM GFEPQIRKIV DQIRPDRQTL MWSATWPKEV RQLAEDFLKD
YVQINIGALQ LSANHNILQI VDVCNDLEKE DKLIRLLEEI MSEKENKTII FVETKRRCDE
LTRRMRRDGW PAMGIHGDKS QQERDWVLNE FRYGKAPILI ATDVASRGLD VEDVKFVINY
DYPNSSEDYI HRIGRTARSQ KTGTAYTFFT PNNMKQASDL ISVLREANQA INPKLIQMAE
DRGGRGRGGR GGYKDDRRDR YSGGGRSNFS GSSYRDSDRG FGSGPKSSFG GSKAQNGGNY
GGNSGNSSGN YGSSNYSNSN GQGNFGAPTN QVGGFGNQSF QGPPQFGGMQ RATQNGMNHP
PFPFNSQPPP PQAQQQPPPP PMVPYTMPPP FPQ
//
