ID A0A3Q2V007_HAPBU Unreviewed; 2598 AA.
AC A0A3Q2V007;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Filamin-C-like {ECO:0000313|Ensembl:ENSHBUP00000003947.1};
GN Name=FLNC {ECO:0000313|Ensembl:ENSHBUP00000003947.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000003947.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000003947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR STRING; 8153.ENSHBUP00000003947; -.
DR Ensembl; ENSHBUT00000009528.1; ENSHBUP00000003947.1; ENSHBUG00000005296.1.
DR GeneTree; ENSGT00940000153588; -.
DR OMA; VPTHEGY; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 255..348
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 350..448
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 449..545
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 546..638
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 642..738
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 739..841
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 842..940
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 941..1036
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1037..1129
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1130..1224
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1225..1324
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1325..1417
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1418..1513
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1514..1610
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1611..1704
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1732..1803
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1803..1895
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1900..1983
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1986..2078
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2076..2175
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2178..2270
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2272..2365
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2369..2461
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2503..2597
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 970..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2598 AA; 277706 MW; 4F84EFDF92B23270 CRC64;
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVNKTVTDL QKDFSDGLKL ISLLEVLSQK
KMYRKHHNRP NFRQMKLENV SVALEFLDRE HIKLVSIDSK AIVDGNLKLI LGLIWTLILH
YSISMPMWDD EDDEEAKKLT PKQRLLGWIQ NKVPQLPINN FNRDWRDGKA LGALVDNCAP
GLCPDWADWD PNKPVQNARE AMQQADDWLG VPQVIAPEEI VDPDVDEHSV MTYLSQFPKA
KLKPGAPLKP RQLFPNKAKA YGPGIEPHGN KVLQPAVFTV ETLEAGSGEV LVYVEDPEGH
KEEAKVKPNN DKNRTYTVTY VPKVEGVHKV KVLFAGQDID KSPYTVNVAK ALGDPSKVQA
RGPGLEPTGN VANKPTYFDI YTAGAGNGDV SVVIVDPQGK KDTVELILEN KGDSVFRCTY
RPVLEGPHKI HVLFAGQEIP KSPFTVNIAE AINPNACRAT GRGLQPTGVR VKEVADFKVF
TKGAGSGALS VSVKGPTGAE EQVKVRDVGN GVYECEYYPL KPGKYTVTIT WGGQPIPRSP
FEVQVGAEAG FQKVRAWGPG LKTGMVGKSA DFVVEAIGTE VGTLGFSIEG PSQAKIECDD
KGDGSCDVRY WPTEPGDYAV HVICDDEDIK DSPFMAHILP AANDVFPEKV KAYGPGLKPT
GVIVNKPAEF TVDARMAGKG QLKIYAQDAE GSTIDIKITD RGDGTFHCVY TPVKPIKHTI
IITWGEVNVP SSPFRVLVGE GSHPDRVKVY GPGVEKTGLK ANEPTYFTVD CSEAGQGDIS
IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGPGR YTIMVLFADQ EIPVSPFKVK
VDPSHDAGKV RAEGPGLNKT GVEVGTPTHF NIYTKGAGKA KPEVHFAASG PGEAVRDFEI
IDNHDYSYTV KYTALQQGNM TISVTHGGDP IPKSPFHITV SPAMDIGKVK VEGLDTKVEV
GKDQEFTVNT KDAGGQGNVG VKMTSPSGRP IPCKLESDKA KGVHSVKYIP PEEGQYKVDV
SYDGNPVMGS PFGVEAVMPA DPSKVRAFGP GLKGGVVGKP APFTIDTKGA GAGGLGLTVE
GPCEAKIECQ DNGDGTCSVA YLPTEPGEYA INILFAEQHI PGSPFKAAVR PAFDPSKVTA
SGPGLERAKA GEPATFTVDC TRAGDGELTI EIVSETGVKA EVHIQKTAEG TFSVTYIPPF
HGTHTITIKY GGNVIPHFPK VLQVEPSVDT TGVHVYGPGV EPRGVLREVT THFIVDARAL
NKVGGNHVKV HIINPSGTNT DTYITDKGDG TYRVEYTAFE DGMHLIEVLY NDAPVPKSPF
RVSVVEGCDP TRVRAFGPGL EGGITNKPNC FTVETRGAGT GGLGLTIEGA SEAKISCKDN
KDGSCSVEYV PFTPGDYDVN INYGGHPIPG SPFRVPVKDP VDPSKVKCSG PGLGAGVRAH
VPQTFTVDCT KAGQAPLDVK LYGPTGTVEP VGVKNNGDGT HTVHYTPAQD GPYTVAVKYA
DQEVPHSPFK VMSQPGHDAS KVRASGPGLD TKGVPASLPV EFTIDARDAG EGLLTVQILD
PEGKPKNATI QDNRDGTYTV SYVPDSTGPY TITIKYGGDE IPYSPYRIQS LPTGDASKCR
VTASLQKLQT SEDTVITVDA KAAGKGKVTC KVLTPQGMEV DMDVVENHDG TFDIYYTAPE
PGKYVITIRF GGQNIPKSPF HVMVSKGLFA SCHSSATNEP VVPRDTVDPL FRPVNFLVPF
TPQQGEITGE VRMPSGKTAR PHITDNKDGT ITIKYQPTEK GLHEMDIKYD GNHIPGSPLQ
FFVDAVNSGV VTAYGPGLSY GMVNKAATFT VVTKNAGEGG LSLAVEGPSK AEITCKDNKD
GTCTVSYLPT APGDYNIIVK FDNKHIPGSP FTAKITGDDS ITRTSQLNVG TAADVSLKIA
ETDLSSLTAS IRAPSGNEEP CLLKRLPNRH LGISFTPKEV GEHEVSVRKN GMHVANSPFK
IMVGQSEIGE ASRVKAFGKG LVEAHTFEMA EFFVDTRNAG YGGLALSIEG PSKVDINCED
VEDGTCRVTY CPTEPGSYTV NIKFAEKHIP GSPFTVKVTG EGRIKESITR KRQASSIASV
GSTCGLNLKI PVESGSQAMT AQVTSPSGKT VDADIMDGGS STYSVRFIPQ EIGPHTVNVK
YRGQHVPGSP FQFTVGPMGE GGAHKVRAGG PGLERGVAGA PSEFSIWTRE AGAGGLSIAV
EGPSKAEISF EDRKDGSCGV SYIVKEPGDY EVSIKFNNEH IPDSPFIVPI ATLSDEARRL
TVTSLQEKDL KVNQEASFMV QRNSARGVVD AKVHTPSGSS EECYVTELDS DKSAIRFIPR
ENGVHSIDVK FNGCHIPGSP FKVRVGDPGL IGDPGMVTAH GPGLQGGTTG VPSEFVVKTC
NAGSGTLSVN IDGPSKVKMD CRECPEGYKI TYTPMAPGNY LITIKYGGPQ HIVGSPFKAK
ITGPRLSGGH SLHETSSVLV ETVTKTSKVG GAYSSSSSTT SSKMTSDASK VVCRGTGLSK
ALVGQKNNFT VDCSTAGTNM LMVGVHGPHA PCEEVYVKHM GNKLYNVTYT VKDKGSYTVI
VKWGDDNVPG SPYKVAVP
//
