ID   A0A3Q2V0U1_HAPBU        Unreviewed;       473 AA.
AC   A0A3Q2V0U1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Iroquois-class homeodomain protein irx-4-like {ECO:0000313|Ensembl:ENSHBUP00000003989.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000003989.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000003989.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC       {ECO:0000256|ARBA:ARBA00008446}.
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DR   RefSeq; XP_005936087.1; XM_005936025.1.
DR   AlphaFoldDB; A0A3Q2V0U1; -.
DR   STRING; 8153.ENSHBUP00000003989; -.
DR   Ensembl; ENSHBUT00000009446.1; ENSHBUP00000003989.1; ENSHBUG00000005281.1.
DR   GeneID; 102295185; -.
DR   CTD; 402999; -.
DR   GeneTree; ENSGT00940000158596; -.
DR   OMA; KTAAEEC; -.
DR   OrthoDB; 2915644at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR003893; Iroquois_homeo.
DR   PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR   PANTHER; PTHR11211:SF16; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-4; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00548; IRO; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          139..202
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        141..203
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          202..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..253
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  52655 MW;  8C22866D57A7397D CRC64;
     MSYPQFGYPY SSAPQFLMTT NSLTTCCEST GRSIADSGVA ASGQTPVYCP VYESRLLATA
     RHELSSAAAL GVYGSPYTSG QGYGNYVTYG TDASAFYSLG TFDTKDATAS AHAGITQATA
     YYPYDPTLGQ YQYDRYGSMD GGTRRKNATR ETTSTLKAWL QEHRKNPYPT KGEKIMLAII
     TKMTLTQVST WFANARRRLK KENKMTWPPR NKGSEEKRYD DDEDGSQEEQ IKSENNDDET
     RSRPDKDLQL SDLDDFDTLE SESSECELKH RYHMNTHMTT TTTDCPGEHL LKDASLKLSI
     PVSLGEEQDL SKNCLKTNHN DGFQSDSRQQ EKACYNQQQG HQILDGKPRI WSLAQTATSL
     NQTEYPSCML RCQPPPSSLT PSPAATSPVT GLDRQDSPVT TLRNWVDGVF HDPLFRHSTL
     SQALTNTTVS WTTNTKGTIL EAERSTSALQ QHQNSSKDSA MSFPKTINKL FCS
//