ID A0A3Q2V2A2_HAPBU Unreviewed; 1244 AA.
AC A0A3Q2V2A2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 {ECO:0000256|ARBA:ARBA00016171};
DE AltName: Full=Membrane-associated guanylate kinase inverted 3 {ECO:0000256|ARBA:ARBA00033438};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000004907.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000004907.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; A0A3Q2V2A2; -.
DR Ensembl; ENSHBUT00000007902.1; ENSHBUP00000004907.1; ENSHBUG00000006329.1.
DR GeneTree; ENSGT00940000156496; -.
DR OMA; PEAKYQG; -.
DR Proteomes; UP000264840; Unplaced.
DR CDD; cd00992; PDZ_signaling; 5.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 5.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF10; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00228; PDZ; 5.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50106; PDZ; 5.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 60..93
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 106..139
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 188..257
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 361..424
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 545..628
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 680..767
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 829..911
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 135164 MW; 45D6CB2E0A4E1930 CRC64;
MDRKDSAAPE EEEEEERPPL VNGLTEHKDK AEWRKTVPSY NQSAGAMDLR IWNTEDESQE
PLPKNWEMAY TETGMVYFID HNSKTTTWLD PRLAKKAKPP EKCDEGELPY GWEKIEDPQF
GTYYVDHINQ KTQFENPVME AKRKLSVDTP IAAPPQAATP SGSTAEEPGR GMRGFTRDPT
QLQGNILKTA LRKSPQGFGF TIIGGDRPDE FLQVKNVLPD GPAAHDKKIA SGDVIVDING
TCVLGKTHAD VVQMFQSIPV NQYVDMVLCR GYPLPEDTSN SEEASSNLSA SKDTSPSPST
PQDLNYAVND GATLSRQTAS VPPMTNGGRH HHPHSHQHHH LPHALNQEGP DPTLLQPELV
SVPLVKGPGG FGFAIADCPL GQKVKMILDA QWCRGLLKGD VIKEINRQNV QTLSHSQVVD
ILKDLPVGSE VNVLVLRGGQ TSPVKSLKPC TGPMSHGVAQ PTSHQAPHSV PQQMVHPFPQ
PTMQQQRQEM ISSTETLSQP EASPNASTFS SSTLRSASPK PDASELYLKS KAILDSKPPN
TKDLDVFIKR NQESGFGFRV LGGEGPDQPV YIGAIVPLGA AEKDGRLRAG DELLCIDGVP
VKGKSHKQVL ELMTNAARNG QVMLTVRRKL AYTDGGGEDD NSQQPQQVAS ALVNSSPKMP
RTEAPSIIQP AQPTRPERFD VTLQRKDNEG FGFVILTSKN KPPPGVIPHK IGRIIEGSPT
DRIGQMKVGD RISAVNGRSI MELSHNDIVQ LIKDAGNIVT LTVVPEDDSA PPSGTNSAKQ
SPSAQHRAVG QQPPSYQDRN GDSEAKNHLS PRDGTGTLIP SGPKQGCFVV ELERSQRGFG
FSLRGGKEYN MGLFILRLAE EGPALKDGRI HVGDQIVEIN GEATQGITHT RAIELIQAGG
NKVHLLLRPG QGLVPDHSSK DKVTIPTSSF PRFSVSDGQS SPASPSSVSL STSELSPSSP
KISAPDEFPG GDGIERGSPG AAREHGRQAN KPRGQQLSDP NHKRTTSPST QTNKTSRSDS
ASGSPKRATE GQREHIDRSQ SPRKTDQGHS GSLEDMSKDR KAQGQRGSKW ERDPAVPLSN
LEEPHSPMRP AGQKPNIASG EEKDLRYKQT DSAYWQERGA TESGDKTWGT TDYYRKAKRA
EQEALVQKSN SQAYRERVGS DADGGTLSRK TGRDKRDKEH RDGKYHGSTE EVNKKDPRGS
NSSIPDPSCN GNTSSKKGPI TPGPWKVPSS AKIQSRVDTT YADI
//
