ID A0A3Q2V2K5_HAPBU Unreviewed; 1305 AA.
AC A0A3Q2V2K5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Neuronal cell adhesion molecule-like {ECO:0000313|Ensembl:ENSHBUP00000004600.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000004600.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000004600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR RefSeq; XP_014184857.1; XM_014329371.1.
DR STRING; 8153.ENSHBUP00000004600; -.
DR Ensembl; ENSHBUT00000008431.1; ENSHBUP00000004600.1; ENSHBUG00000006122.1.
DR GeneID; 102313394; -.
DR CTD; 556537; -.
DR GeneTree; ENSGT00940000155419; -.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1305
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018713383"
FT TRANSMEM 1167..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 140..230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 244..332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 337..424
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 430..517
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 521..608
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 625..720
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 722..819
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 824..927
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 931..1027
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1062..1154
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 705..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1305 AA; 144566 MW; 5AE2C9ECA28A851C CRC64;
MDRNRKWVPG FGAVLLTLLS HMTSALEVPL DPKVLEGLPQ PPTIILQSPK DYIFDPRENI
VIHCEAKGKP HPSFSWTRNG THFDVEKDSK VLMKPGSGTL VIDISSERAE AYEGTYQCIA
NNEHGTAVSD SIVIRQSRSP LWSKERNEAI MVQKGVSLVL QCRPPAGLPP PVIFWMDNNF
QKLPLDKRVS QALNGDLYFS NVLPEDTRSD YICYARFPHT QTIQQKQPIS VTVLDSSPEG
ERRPGFMLPL GTISTKMVLR GQTLELECIA EGLPTPDISW QKEGGELPSN RVSYQNFKKT
LKISDVNEND AGNFRCIATN NLGTVHHTIK VTVKAAPFWV SIPRNLILAP NETGVLTCRV
NGEPKPRIDW FVNGIPIENT PEDPSRKVED DTVILSNVQS GSSSVYQCNA SNEFGYLLAN
AFVSVLAEPP RVLTPPNQVY QVITNSPALL HCASFGSPIP TITWFKDSQI SIKNTDPYVI
HENGTLEINV AQPLNSGKYT CIATNNLGIK ENHVFLEVKE PTRILKQPEY KVVQRGMSAV
FECKVKHDPS LIPTMTWLKD RGELPDDERF EVDTDSLTIR DVTDDDKGTY TCIMNTTLDQ
DSASAMLTVV EATPTPAIVY EKPDPPTDLE LTDQTEKSVQ LTWTPGDENN SPIEKFLIQY
EDLLHQPGVW TNLTEVPGTS TTAQLHLSPY VYYSFRALAK NRVGYSEPSQ SSRQYRTNPA
APDENPSGVQ GVGTEPGNLV ISWTPLTGLQ SNGPGLEYKV QWRQKDVEKE WSAQNVANVS
QWVVSGTPTY VPYEIKVQAF NDYGVGPEPE VAFGYSGEDL PLSAPESVQV MVHNSTLAEV
HWEPISPPSV RGKLQGYKVY YRRKHGLHET EEETDQEMQV LTFSGNRSEG RLPGLQPYSV
YSLSIRVLNN KGEGPSSQSK TFETPEGVPG PPSFLSVINP GLDSLTLEWG PPINNNGRLT
GYILKYQPVN NTSELGPVQV MTFLANETTI TLSNLNSSML YKFYLSAKTN KGEGPIITEE
AFTVMHTTRT RPTVEAGKGP TEPPHPTSPI TQSLHSPFHK APPVGRAFGT VNTSVSEDSA
VISWEYFGHH KNVYVEYIVE NSKEEWKKEF ANGSHSHTIK GLKPGTSYRV KVIAKDAADP
TVHSTDEMLV TVPAVASRQV DIATQGWFIG LMCAIALLIL VLLIVCFIKR NKGGKYPVKE
KEDAHQDPEI QPMKEDDGTF GEYRSMESDT EDHKPLKGSR TPSNGTVRRD ESDDSLVDYG
EGGDGQFNED GSFIGQYSGK KEKDTHEGNE SSEAPSPVNA MNSFV
//
