ID A0A3Q2V2K7_HAPBU Unreviewed; 611 AA.
AC A0A3Q2V2K7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Transcription factor E2-alpha {ECO:0000256|ARBA:ARBA00041064};
DE AltName: Full=Transcription factor 3 {ECO:0000256|ARBA:ARBA00041234};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000004679.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000004679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q2V2K7; -.
DR Ensembl; ENSHBUT00000008296.1; ENSHBUP00000004679.1; ENSHBUG00000006086.1.
DR GeneTree; ENSGT00940000157036; -.
DR OMA; TRCQPTP; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18945; bHLH_E-protein_TCF4_E2-2; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR11793:SF7; TRANSCRIPTION FACTOR E2-ALPHA; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 505..558
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 45..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 65467 MW; 5989F3160024F661 CRC64;
MNEQQQRMAA VETDKELSDL LDFSAMFAPP VANGKNRTMT LASSQFGGSA IDERSGSGSW
GSAEQNSPSF SQGRGYGEGS HYSEHEALSS PFISSGIAGK NERPPYSSFG NQPGFLPSDI
AMPSPDAMSP SGLKSGSQFY PSYPNNPRRR PPEGAIETQP KKIRKPPGLP SSVYASTSGD
EYTRENGGYP GAKPGVYPTS FYLQDDPWSS SGYSAMLGNS PHIGQPGSFS AINPQDRMNY
PLHSSEVNGF HSAPTTYNHT PTINGEGIMA NRGTTAGSSG DEIGKALASI YPSDHNSNNF
SSAPSTPGSP QAIAGPQSQW QRPTTPNYEG PPHALQSKME DRLEEAIHVL RSHAVGQGPG
LEGAHSDMHS LLSSVHNGGL GGLSPAFPNA SLALSNRHPA MGGKHEEPTG LPPSSTLLHG
HHASGPTPAV SQPEGFTSLP GGLARSSHSS SSSDIKREDK EDDENSSVAD KSEEEKKDTK
AARSRTSQED DEDLPPEVKM ERERERRVAN NARERLRVRD INEAFKELGR MCQLHLSHDK
PQTKLLILHQ AVNVILNLEQ QVRERNLNPK AACLKRREEE KVSGVVGEAP MQLSGGHPSM
GGDGHNPVGH M
//
