ID A0A3Q2V3X1_HAPBU Unreviewed; 1030 AA.
AC A0A3Q2V3X1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Adhesion G-protein coupled receptor D2-like {ECO:0000313|Ensembl:ENSHBUP00000005592.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000005592.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000005592.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR AlphaFoldDB; A0A3Q2V3X1; -.
DR STRING; 8153.ENSHBUP00000005592; -.
DR Ensembl; ENSHBUT00000006725.1; ENSHBUP00000005592.1; ENSHBUG00000006998.1.
DR GeneTree; ENSGT00940000161534; -.
DR OMA; CWICNEA; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF58; ADHESION G-PROTEIN COUPLED RECEPTOR D2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 647..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 868..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 644..891
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 914..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 113575 MW; 0A16FAFA29D9BA7C CRC64;
MCKQRSGALA IVSNAEENRE LTKFLKSLNI SQSVWIAKKV ITRITTSSKT LILNFTGRSN
RTHARLRYSF PSMGSLTVCT LLRFNPHCSG RSTVFSYSIP SYINEFQLRA NLNQGKPVQL
ALLVHGIHGP YHDAFNYDDS WHSVCVSWSQ NGGRWAIYAH GHAVSAAEGL NSTDSIGPGG
FFIIGQEQDT FGGSFKSDES FSGSITELHI WNRVLNSSEI SSMEKKCSLV SSGLVFKWSE
AAMEIETSLT KQWSDSPCQE SQRTDEECGI FDPVTEHSRL AKCNSSRGAV CQCRREKLGV
FSLPKTPFFR RLNKDLINKP VTGGVGANSS WDKLTLLQQL TQAVLHKIEA SGPLLLTAND
VFYLSQMMDV TPPARFHSAG DNATEVMVSI ATNYLNIASL ILEPRMASQW MGLTDDGVNI
GPFTLVKTID KFTEAFAEML CTKGRSLSLS TKNIDVYMKW QKLSQESCNQ VYKPSAFGSH
KPSSSSHDEL LIPETELQRI HTLGYEEVIF IHTHYNQFSD IVSGTKESAL SDQEKVKRTL
PGDLASAIIS ATVRHASNPE TIPVAVKYTL SSSQVEYSKR VIPVCAFWNF SLTHTNTSSW
SSEGCTVILD GSSVTSCLCN HTTNFAVLMN YLESQWSPEE ELILTKLTFI GCGASLCALV
VTLMLFTVLD IPKSDRTSIH KNLFVALICA QVILLCSGSA IHNKVACTLV AALLHLFFMA
AFSWMLVEGL LLWSKVVAVN LSEEQHMKYY YLIGWGLPVL IVTITLASAP SKYSADDYCW
LSLQNGIIWG FAGPVIFIIM VNILVLTRVV VITISTAKRR SIMLAMGASP VERTYEQIRA
AVKAVLVLLP ILGLTWLCGV LVPLSIVMAY VFILLNSLQG LFIFLIYGVY NTEVRSTVNR
IKERRKALNF SNCASSRPSS SVTNSRPVSF PLGTTPSQEE EGYACSTTLG PAMQEENSQV
EVSIPCVPEI VENGQMSEGT HLDTEELPAS EVNALPPGCS LHVPMDLEFS ASCFPRSPTP
QKSYDLVHID
//
