ID   A0A3Q2V5D8_HAPBU        Unreviewed;       548 AA.
AC   A0A3Q2V5D8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Thyroid peroxidase {ECO:0008006|Google:ProtNLM};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000002458.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000002458.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2V5D8; -.
DR   Ensembl; ENSHBUT00000012061.1; ENSHBUP00000002458.1; ENSHBUG00000004105.1.
DR   GeneTree; ENSGT00940000158104; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   PANTHER; PTHR11475:SF60; THYROID PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   BINDING         397
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   548 AA;  62065 MW;  4641A0B603FA0DD4 CRC64;
     LARWTKPSAS QHMLKFFRQA DPETKHISRA AEVFQKTLRV LKKKVKQRYN QEKLDDAFSK
     GLYSFAWQYF WTHFMFLFVR QNPRWGAANT ALVRWLPAEY EDGESEPKGW NPERLHNGFQ
     LPPARTVSRE IMTSASKWKD DSYSQLLVDW GQYISHDITL TPQSTSTDGS DVDCLKTCEN
     VHPCFPIKMN DGLQGCMPFF RSTSDCFVNF QSGIRQALQR QQLNAMTSFI DASAVYGHNQ
     KLESFLRDLP GRNGKLAVNA RFKDPKGRPY LPFVTKLPSA CHQDLQGERV ECFSAGDNRV
     SEGLPLTSLH TLWLREHNRI AEALKHINGH WSPEMIYQET RKIIGALHQI ITLRDYAPKI
     IGPESFKHYI GPYRGYDPSV DPSIANVFAA AAFRFGHATI SPILCRLNES FQEDERFPHL
     RLHNTLFSPW RIVKEGGIEP VLRGVIGSAA SAVSADMLLA DEVTERLVVL DTLKQMDLAA
     LNLQRGRDHG LPGKILAESQ ICHSNAIRLS SSRKTTPKHN VPDFVLDCVG GSSHFSPSLL
     CSLANRQT
//