ID A0A3Q2V5M6_HAPBU Unreviewed; 183 AA.
AC A0A3Q2V5M6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000006277.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000006277.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00023421};
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004238}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004238}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004238}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004523}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004523}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004523}.
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DR RefSeq; XP_005920066.1; XM_005920004.2.
DR AlphaFoldDB; A0A3Q2V5M6; -.
DR STRING; 8153.ENSHBUP00000006277; -.
DR Ensembl; ENSHBUT00000005581.1; ENSHBUP00000006277.1; ENSHBUG00000007655.1.
DR GeneID; 102296551; -.
DR GeneTree; ENSGT00940000160594; -.
DR OMA; CSAKNNH; -.
DR OrthoDB; 8685at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0032486; P:Rap protein signal transduction; IEA:InterPro.
DR CDD; cd04176; Rap2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041840; Rap2.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR020849; Small_GTPase_Ras-type.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24070; RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY; 1.
DR PANTHER; PTHR24070:SF221; RAS-RELATED PROTEIN RAP-2A; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
SQ SEQUENCE 183 AA; 20693 MW; B36E829713822E74 CRC64;
MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG
TEQFASMRDL YIRNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYQQVP VVLVGNKVDL
EDEREVSPSE GQALAEDWGC PFMETSAKSK TMVDELFAEI VRQMDFCPLP DRREACCPAC
SIQ
//
