ID   A0A3Q2V7L2_HAPBU        Unreviewed;       279 AA.
AC   A0A3Q2V7L2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Oxidoreductase HTATIP2 {ECO:0000256|ARBA:ARBA00039778};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000007122.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000007122.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000256|ARBA:ARBA00004259}.
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DR   RefSeq; XP_005942120.1; XM_005942058.1.
DR   RefSeq; XP_005942122.1; XM_005942060.1.
DR   AlphaFoldDB; A0A3Q2V7L2; -.
DR   STRING; 8153.ENSHBUP00000007122; -.
DR   Ensembl; ENSHBUT00000004157.1; ENSHBUP00000007122.1; ENSHBUG00000008629.1.
DR   GeneID; 102289651; -.
DR   CTD; 10553; -.
DR   GeneTree; ENSGT00390000008184; -.
DR   OrthoDB; 150138at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   CDD; cd05250; CC3_like_SDR_a; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   PANTHER; PTHR14097; OXIDOREDUCTASE HTATIP2; 1.
DR   PANTHER; PTHR14097:SF7; OXIDOREDUCTASE HTATIP2; 1.
DR   Pfam; PF13460; NAD_binding_10; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          60..161
FT                   /note="Semialdehyde dehydrogenase NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00859"
SQ   SEQUENCE   279 AA;  30973 MW;  730C082814CB82DF CRC64;
     MPVIKLLCTT LGKTLGFFTV LVVFIAATLN YFEDSETVKY TSMAEDIKTL EENFRQQNKS
     CFILGASGET GKLLLQELLE HNIFSKITLI GRRQLTFEGK TYENLVQEVV DFEKLDDYAA
     AFQGHDVGYC CLGTTRAKAG AEGFVRVDHD YVLKSAELAK AGGCTQFHLE SSRGADKKSG
     FLYLKVKGQV EADIEALGFD RFAIYRPGVL LVDRQESRPA EWMARKFFSA VSAVGYRSMS
     VPIQEVAKAM VSNTVLQPEQ KMEILENKDI ATLGKSAGK
//