ID A0A3Q2V988_HAPBU Unreviewed; 609 AA.
AC A0A3Q2V988;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Dynein axonemal assembly factor 1 {ECO:0000256|ARBA:ARBA00024429, ECO:0000256|RuleBase:RU364076};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000007270.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000007270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cilium-specific protein required for the stability of the
CC ciliary architecture. Plays a role in cytoplasmic preassembly of dynein
CC arms. Involved in regulation of microtubule-based cilia and actin-based
CC brush border microvilli. {ECO:0000256|RuleBase:RU364076}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU364076}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family.
CC {ECO:0000256|ARBA:ARBA00006453, ECO:0000256|RuleBase:RU364076}.
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DR RefSeq; XP_005944739.1; XM_005944677.2.
DR AlphaFoldDB; A0A3Q2V988; -.
DR STRING; 8153.ENSHBUP00000007270; -.
DR Ensembl; ENSHBUT00000003921.1; ENSHBUP00000007270.1; ENSHBUG00000008736.1.
DR GeneID; 102305961; -.
DR CTD; 123872; -.
DR GeneTree; ENSGT00940000158494; -.
DR OMA; DTQDHSP; -.
DR OrthoDB; 129594at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF19; DYNEIN AXONEMAL ASSEMBLY FACTOR 1; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|RuleBase:RU364076};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU364076};
KW Leucine-rich repeat {ECO:0000256|RuleBase:RU364076};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|RuleBase:RU364076}.
FT REGION 26..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 68774 MW; 449E7419372A1AD8 CRC64;
MFLISILTIS TSENQERMED QVLVATEVEG GDARESSDSS GAQEDLGKKE LQSSPQEKNE
KHSGPRMTKK FLRDHCKQNK LYITPCHNDV LYLHFKGFST IENLEEYTGL KCLWLESNGL
QRIENLDAQT DLRCLFLQQN LIYKLENLEP LKKLCTLNVS NNYIHIIENI SCLPDLSTLQ
IAHNKLETVG DIEHLSQCLN ISVLDLSHNL LHDPDILPVL EAMPELRVLN LMGNEVVKKI
PNYRKNMIVR LKQLTFLDDR PVFPKDRACA ESWAVGGLEG ERQEREQWDT RERKKIQESL
DGMAMIRKKA QERRRLRELQ DKGKTDASST PETTTEENGT QILTSSQGDK IQAFVQDCLD
VYEEFLEKQS KQGLLENQPA SKHLETKEAG QLLMREQLDE DTQDHSPITH TVREEKGREK
IPADEQGSTV GHMLETENKQ EKQSKRNEAE REQSKNKQPP LPEADDDVLV HSPGPRITEL
QDAELLETIH LPPASRSLRI DELPDLEDVD TEDFNAAFSC RQAFKPKIEV ISGDSNREAP
AGIQSDSIST SAPAKSFLFL TSGCDKSPAV SGNSTSLVYP EDEGAPSDPL NSKINRTSSP
PCCLIEELE
//
