ID A0A3Q2VA56_HAPBU Unreviewed; 1185 AA.
AC A0A3Q2VA56;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Thrombospondin 2 {ECO:0000313|Ensembl:ENSHBUP00000007609.1};
GN Name=THBS2 {ECO:0000313|Ensembl:ENSHBUP00000007609.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000007609.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000007609.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005915524.1; XM_005915462.2.
DR RefSeq; XP_005915525.1; XM_005915463.2.
DR AlphaFoldDB; A0A3Q2VA56; -.
DR STRING; 8153.ENSHBUP00000007609; -.
DR Ensembl; ENSHBUT00000003351.1; ENSHBUP00000007609.1; ENSHBUG00000009211.1.
DR GeneID; 102305848; -.
DR CTD; 100535241; -.
DR GeneTree; ENSGT00940000157846; -.
DR OrthoDB; 5345349at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF10; THROMBOSPONDIN-2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF00090; TSP_1; 3.
DR Pfam; PF02412; TSP_3; 6.
DR Pfam; PF05735; TSP_C; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00209; TSP1; 3.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50092; TSP1; 3.
DR PROSITE; PS51234; TSP3; 4.
DR PROSITE; PS51236; TSP_CTER; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1185
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018640314"
FT DOMAIN 323..380
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 652..694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 733..768
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 792..827
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 889..924
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 925..960
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 964..1178
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 730..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 131761 MW; 314931595B2E9D42 CRC64;
MILRRSLFLL LLSFNYLQAL TEDGEQEDET SFDLFEISDI TRRTLGAKQF RGQNLDAPAY
RFIRFDHLPP VSPPILKQML HQIQNNEGFV FVASIRQDRS SRGTLIGLEG PDGRRQFEIV
SNGRANTLDL VYWADGSQNV VSFEDVDLSD SQWKNITLHV HGENANLFVG CSLIDSFILD
EPFYEHLKAE GSRMYVAKGS IRENHFRGLL QSVRFIFDTS IEDILLSRDC EITKQDDANI
VSESGEIVDV SPSITTNVIG QKTDDVGAEM CERSCEELST MFQELKGLRI VVSNLIDGLQ
KVTEENSVMK DALGRMKNSS EKNMCWQDGR LFDDKEDWVV DSCTKCTCQE SKIVCHQITC
PPVACASPSF IDGECCPACL PMDSDDGWSP WSEWTECTVT CGIGTQQRGR SCDATSNPCT
GPSIQTRKCS LGKCDSRVRQ DGGWSLWSPW SSCSVTCGEG QITRIRHCNA PVPQLGGRDC
EGSGRETQGC TAKPCPIDGG WGPWSPWATC SATCGGGHKS RSRECNSPEP QYGGKKCFGE
AVDRDSCNKN DCPIDGCLSN PCFAGVDCSS SADGSWECGP CPAGFRGNGT HCEDINECDM
VSDVCYKVNG MQRCVNTDPG FHCLPCPKRY KGTQPFGMGV EAAKKNKQVC EPENPCKDRT
HNCHKYAECI YISHFSDPMY KCECRTGYAG DGFICGEDSD LDGWPNQNLV CGANATYHCK
KDNCPSLPNS GQEDFDRDGQ GDACDKDDDN DGILDERDNC PLLYNPRQFD FDKDEVGDRC
DNCPYEHNPA QIDTDHNGEG DACAVDIDGD GILNENDNCP YVYNTDQKDT DMDGVGDQCD
NCPLLHNPDQ TDLDNDLVGD QCDNSQDIDE DGHQNNLDNC PYVANSNQAD HDKDGKGDAC
DYDDDNDGIP DDRDNCRLTP NEDQEDSDGD GRGDACKDDF DNDSIPDILD VCPENNAISV
TDFRKFQMVH LDPKGTTQID PNWVVRHQGK ELVQTANSDP GIAVGFDEFS AVDFSGTMYV
NTDRDDDYAG FVFGYQSSGR FYVVMWKQIT QTYWEDKPSK AFGISGVSLK VVNSTTGTGE
YLRNALWHTG NTPGQVRTLW HDPKNIGWKD YTAYRWHLIH RPKTGFIRVV VYEGKQIMAD
SGPIYDKTFA GGRLGLFVFS QELVFFSDLK YECRDKPELP TVLTR
//
