ID A0A3Q2VAF6_HAPBU Unreviewed; 1043 AA.
AC A0A3Q2VAF6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FERM domain containing 4A {ECO:0000313|Ensembl:ENSHBUP00000008332.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008332.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000008332.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q2VAF6; -.
DR Ensembl; ENSHBUT00000002133.1; ENSHBUP00000008332.1; ENSHBUG00000010208.1.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17199; FERM_F1_FRMD4A; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF3; FERM DOMAIN-CONTAINING PROTEIN 4A; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 16..319
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 362..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1043
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 115029 MW; BFE07964B7090B4C CRC64;
MEGLLSPMRT RMTEGRRCQV HLLDDRKLEL LVQPKLMAKD LLDLVASHFN LKEKEYFGIA
YTDETGHFSW LQLDRRVLEH EFPKKSGPIV LYFCVRFYIE SISYLKDNAT IELFFLNAKS
IIYKELIEVD SEVVFELASY ILQEAKGDFT SNDATRSDLK KLPALPTQAL KEHPSLAYCE
DRVIEHYKKL SGQSRGQAIV NYMSIVESLP TYGVHYYSVK DKQGIPWWLG LSYKGIFQYD
YQDKVKPRKV FQWRQLENLY FREKKFSVEV HDPRSRASVT RRTFGHSGIA VHTWYACPAL
IKSIWAMAIS QHQFYLDRKQ SKSKIHAARS LSEIAIDLTE TGTLKTSKLA NMGSKGKIIS
GSSGSLLSSG SQESDSSQTA KKDMLAALRA RQEALEETLK QRLEELKSIC IREAELTGKL
PKEYPLDPGE EPPTVRRKIG TAFKLDEQKI LPKGEEEELE RLEREFAIQS QITEAARRLA
SDPHVSSKKL KKQRKTSYLN ALKKLQEIEN SINEYRVRSG KKPTQRASLI IEEANIGSED
SSLSDALVLD DDDPQVTGTP TFSPVASPHK GLPPRPPSHS RPPPPQSLDG LRHLHYTRSD
YDKSPIKPKM WSESSLDEPY EKVKKRSSHS SHRRFPSSGS AEAGGSNSLQ SSPIRSLPHW
NSQSSMPSTP DLRTRTPHYV HSTRSVDISP TRLHSLSQHF RNRSSSLESQ GKLLASDSDA
HPHTLGSPDF FLGPGRSSNG SDPLDDCSSC TSQSSSEHYY PSGGPPGSNP NYSTLGEDSP
SKARQRQRQR HRSAGHLGSS NSGSMPNLAA KNGSGGGLGG SGVGGGHHGV YLHSQSQPSS
QYRIKEYPLY VEGSPNPVVV RSLESDQEGH YSVKAQFKTS SSYTAGGLYK EAWGGEEGGE
GSGRLTPSRS QIVRTPSLGR EGGGGGGGGR AAVSEELRCW YQRSSGSLKE RSHSHSGSTS
SETGSQQGTL GHGRGSRVGT LAKGSPAASP HSQRSMTPSS EHAATPTPPC SPQHILNWQS
GGTADCSPTE DVCQSPPQPS SDA
//
