ID A0A3Q2VAQ8_HAPBU Unreviewed; 986 AA.
AC A0A3Q2VAQ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=EGF like, fibronectin type III and laminin G domains {ECO:0000313|Ensembl:ENSHBUP00000007834.1};
GN Name=EGFLAM {ECO:0000313|Ensembl:ENSHBUP00000007834.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000007834.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000007834.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q2VAQ8; -.
DR Ensembl; ENSHBUT00000002984.1; ENSHBUP00000007834.1; ENSHBUG00000009496.1.
DR GeneTree; ENSGT00940000158504; -.
DR OMA; CGEGTIE; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF88; PIKACHURIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00054; Laminin_G_1; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 34..134
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 142..237
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 324..362
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 364..542
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 543..580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 587..766
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 762..798
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 805..984
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 333..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 352..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 570..579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 788..797
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 957..984
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 986 AA; 108574 MW; 6A8AD20380EF63B4 CRC64;
MVHTLQEILC IFFFQKTKTT NKCLNSNTEK TFLPPLDIQL ETINCTAFSV RWKMPRRHVS
TITGYKVFYT EMKNGRTVGT ASIMEVPLSL DMLTTDVDIS NLKVNTNYRV SVGAYGWAGE
GRPSMPRDIG TASQEMCMPP SPPSKPTVMA VSDTELALSW QQGESDGSAP VLHFLVAYIR
PEMDTEWTYI REPIETNSMV LKGLIPETEY QFVVRAVNKH GVSPPSPINN PVRTLGKAEY
VGSGDYGSYI TDPRVKDEDG FDIDDSDYDI FIEEVCFLQS RAKLNRLLKF LIFLSLFILQ
SIPLSTTTST TTTSPWKGEV PRVYDLSCDD TVCPPDSFCL TDYESGGSRC HCNLGRRGDT
CSEVKFPRFH GHSHMTFEPL KNSYQTFQIT LEFKADSEDG LLLYCGENEH GRGDFTSLAL
VRGKLHYRFN CGTGAAQIVS ESRIVLGQWH TVTVFRDGMS GWLRMDNDTP ISGRSQGQYS
KITFRSPLHV GGSPSAYWLV KATGTNRGFV GCMQSLTINN KATDIRPWPL GSALSGADIG
ECSDNVCDLV SCANGGVCFA NRADGYICLC PLGFRGALCE ESFSLSSPLF NETVFSYAVI
PWPQSSQSYL SFTEFEVTFQ PSAPDGVLLY SDDAGSGDFL AINLVDRYVE FRFDCGSGGA
VIRSEEQISL DSWHELRVSR TAKSGILQVD SQRPMEGIAE GAFTQINCSS PLYIGGVPEY
DKTKRTAGVI KPFTGIIQKL ILNDRTIPIT TATAGGVNVA NSAHPCVESP CANGGSCRPK
WDEYECDCPL GYDGRHCQKA VTEAIEIPQF IGRSYLTYDN RDILKRVSGS RSSLFMRFKS
TAKDGLLLWR GDSPMRPNSD FLSMGLQDGA LIFSYNLGSG VANIVINGTF SDGKWHRVKA
VRDGQSGKLT VDDYGAKTGR APGKMRQLNI NGPLYVGGMK EIALHTNRQY IGGLVGCVSH
FTLSTDYHLA LVEDAADGKN INTCSN
//
