ID A0A3Q2VBF3_HAPBU Unreviewed; 1123 AA.
AC A0A3Q2VBF3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 5-like {ECO:0000313|Ensembl:ENSHBUP00000004868.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000004868.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000004868.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_005931817.1; XM_005931755.2.
DR AlphaFoldDB; A0A3Q2VBF3; -.
DR STRING; 8153.ENSHBUP00000004868; -.
DR Ensembl; ENSHBUT00000007970.1; ENSHBUP00000004868.1; ENSHBUG00000006258.1.
DR GeneID; 102296309; -.
DR CTD; 797331; -.
DR GeneTree; ENSGT00940000165387; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 104..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..283
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 400..683
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 697..809
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 829..958
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1055..1123
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 123457 MW; 3B47508FE2006CEB CRC64;
MLNNMTDCEE GEGGPNSQGD GNPKESSPFI NSSAATNMDK SQQYDGNNMA LFEEEMDTSP
MVSSLLSTLA NYSNLPTGSK EHEEAENNED GSRPSKKPVK APQLGTLMGV YLPCIQNIFG
VILFLRMTWM VGIGGVFGSF IIVFMCCSTT MLTAISMSAI ATNGVVPAGG SYYMISRSLG
PEFGGAVGIC FYLGTTFAGA MYILGCIEIL LIYIVPQAAI FKIEGLEGPE AEAALLNNMR
VYGTIVLSLM ALVVFVGVKY VNKLALVFLA CVILSILSVY AGVIKTAIDP PVFPVCLLGN
RTLLSKGYDV CAKVIEIDNE TVTTKLWRSF CDSEYLNATC DEYFNNNNVT EIQGIPGVTS
GILAENLFGN YLEKGMILEK RGLVSDVDPD SPTTSSNRYV LADITSFFTL LVGIYFPSVT
GIMAGSNRSG DLRDAQKSIP IGTIAAISTT STVYMSCVVL FGACIEGVVL RDKFGEGVSG
NLVIGTLAWP SPWVIVFGSF FSTCGAGLQS LTGAPRLLQA ISRDGIIPFL RIFGHGKANG
EPTWALLLTA SICEIGIIIA SLDSVAPILS MFFLMCYMFV NLACALQTLL RTPNWRPRFK
FYHWALSFLG MSLCLSLMFM CSWYYAIVAM GIATCIYKYI EFCGAEKEWG DGIRGISLSA
ARFALMRLEE GPPHTKNWRP QILVLVSMDA EQNIEQPRLL SLTNQLKAGK GLTIVGTCVQ
GTFLDNYTEA HKADQSLRKL METEKVKGFT QVVISSNLRD GTSHLIQVGG LGGLKHNTVM
VSWPRNWKQP ECHQEFRNFI EVVRETTIAS IALLVPKNIS SYPSNGERFT EGHIDVWWVV
HDGGMLMLLP FLLRQHKVWR KCKMRIFTVA QMDDNSIQMK KDLITFLYHL RIDAVVEVVE
MHDGDISAYT YEKTLIMEQR SQILKQMHLT KNEMEREIQS ITDSSRGSIR RKNPSALRSQ
RSAEEGAGAA EKLEEEPGAV SNPKQVQLSH SKNVSTPTSP TSPTSPAAPA GGAVVWPDNK
GAEKERSLLT ATSEAGKDFL HMKPEWENLN QTDVRRMHTA MRLNEVITKK SKEAKLVLLN
MPGPPKNRVG EENYMEFLEV LTEGLNRVLL VRGGGREVIT IYS
//
