ID   A0A3Q2VBG7_HAPBU        Unreviewed;       789 AA.
AC   A0A3Q2VBG7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Protocadherin 1 alpha 4 {ECO:0000313|Ensembl:ENSHBUP00000008129.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008129.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000008129.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2VBG7; -.
DR   Ensembl; ENSHBUT00000002509.1; ENSHBUP00000008129.1; ENSHBUG00000000251.1.
DR   GeneTree; ENSGT00940000164173; -.
DR   OMA; SVPFKLM; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF287; CADHERIN-RELATED NEURONAL RECEPTOR VARIABLE 1-RELATED; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..789
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018684563"
FT   TRANSMEM        687..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          69..128
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          129..237
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          238..345
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          346..450
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          451..560
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          574..672
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   789 AA;  86762 MW;  4C661EA107283A66 CRC64;
     MRTQWDNIWS LFFSLLCLCE WSVAQISYSI FEEVDKGAAV GNLAKDLNLS VQQLQSAGLQ
     ITSGYKPPYF DINLESGVLF VSERIDREEL CPNTVKCSLN IEAILSNPRS LHRIEVVIND
     INDNAPSFLE DIFTIDMSES SYVGERHPLP IAHDPDVGAN SVKTYKLNAN DYFSLDIQST
     GDQSVSAELV LQKALDREKQ AVIELTLTAI DGGKSPKTGT LQIQVNVLDV NDNSPVFSKS
     LYKVQVIENA NIGTTILKLN ATDLDEGSNS DVRYSLLKRG NVDSPEKFIV IPESGEIIVK
     GNLDYEESTA YELRVRASDQ GASPRSGYSK VLLEIVDVND NAPQISVTSL MSPVKENAEI
     GTVVALVTVT DKDGGQNGLT TCKLKDSIPF KLKSNYRNYY SIVVNGQLDR ETLSQYSVTI
     IATDEGSPPL SSSAVITVHI SDVNDNAPSF PDGYINIYVK ENSKVGDIIT KVTACDADTN
     ENAKLTYSLI ENYPNQFSIS TVLNINSETG DIISLQSFNY EELKMFHFKV QATDSGVPPL
     SSNVTVNVLI LDENDNSPTI LAPYSEHGSV NSESIPYSAE AGYFVAKIRA VDADSGYNAL
     LSYHLSEPKG NNLFRIGTST GEIRTKRRMS DNDLKTHPLV VLVSDNGEPS LSATVSIDVV
     VVESTAEIQT QFRHMPVKED SFSDLNLYLL IAIVSVSVIF LLSLITLIAV RCHRTDGTFS
     RYSAPMITTH PDGSWSYSKA TQQYDVCFSS DTLKSDVVVF PFKDTLGLYC GEKGCCCWIM
     VFIADIYRI
//