ID A0A3Q2VFV2_HAPBU Unreviewed; 839 AA.
AC A0A3Q2VFV2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Zinc fingers and homeoboxes protein 1 {ECO:0000256|ARBA:ARBA00040117};
GN Name=ZHX1 {ECO:0000313|Ensembl:ENSHBUP00000010045.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000010045.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000010045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR AlphaFoldDB; A0A3Q2VFV2; -.
DR STRING; 8153.ENSHBUP00000010045; -.
DR Ensembl; ENSHBUT00000016800.1; ENSHBUP00000010045.1; ENSHBUG00000011620.1.
DR GeneTree; ENSGT00950000182893; -.
DR OMA; HHLSATN; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 5.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR PANTHER; PTHR15467:SF4; ZINC FINGERS AND HOMEOBOXES PROTEIN 1; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR Pfam; PF11569; Homez; 1.
DR SMART; SM00389; HOX; 5.
DR SUPFAM; SSF46689; Homeodomain-like; 5.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 265..308
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 426..486
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 545..595
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 619..679
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 267..309
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 428..487
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 547..596
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 621..680
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..726
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..821
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 92704 MW; 22A56529650A22E5 CRC64;
MSSRRKSTTP CMVVPSDVVE QEQEEVEEKT EKTKEEDAGE EEEGKVKEGT EEGIHRCAVN
NECCIIVTVY TTDEPGVSTV DNREAVGPSL KSSTTNPPED LSSDQPTHEQ QCDTPEEGGA
DPAAVAAISL SKTPIMRMKT KSEPKRIAVS LKSADEAAEA FGGGGDGELG GEQEPIEAPP
GPMTPVEMLM HDSMKLGGGG LLITPQFEQQ RKSSILNPTV LPAGLAQVLS AFQAQQNTAA
VQPQLLIPLS SIPSYSAAMD TNPLLGTTYK KFPYPSMAEI SSLAAQTQFT EEQIKVWFSA
QRLKHGVSWT PEEVEEARRK QFNGTVHTVP QTITVIPAHQ LSAAANGLQS ILQTCQIVGQ
SGLVFTQVGG NLPVTSPITL TVAGLPSQSQ SSSRVSCQPT LTNSELKRAT TIQPPSLSPQ
NSALSVDTFS MRPKKSKEQL AELKASYLKN HFVTDAEIAR LMKLTNLTKG EIKKWFSDTR
YNQRNSKNSH VIVSAANTTI VIDSSDETPT SPHPPRTPPV KEKETRPKTW NPFPDFTLQK
FKEKTPEQLV VLEESFEKNT TPSDEELSRL RTETKLTRRE IDAWFTERRK MPSVSTSSPD
SSEGGKIETD GAKAGEGGGT GATDKSKKTP EQLHILKSAF VRTQWPTPEE YDQLAEESGL
PRSYIVSWFG DSRYSWKNGN LKWFFQYQSG NIEGPNSGGG SKLGSGSRKR RGRNRGWGRS
RTRKQPRRST SLSSDVDRPT PSKKFKTGKE ILKEYYLKHH FLNEQDLDEL VTKTNMSYEQ
VREWFAEVQR RLDGGLDPFL EPNEEDEEED EEEDGDDTDD SEVWEPSRSV KKSLSVSED
//
