ID A0A3Q2VIH7_HAPBU Unreviewed; 176 AA.
AC A0A3Q2VIH7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Alpha-crystallin A chain {ECO:0000256|ARBA:ARBA00018827};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000011527.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000011527.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000256|PIRNR:PIRNR036514, ECO:0000256|PROSITE-ProRule:PRU00285,
CC ECO:0000256|RuleBase:RU003616}.
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DR RefSeq; XP_005952707.1; XM_005952645.1.
DR AlphaFoldDB; A0A3Q2VIH7; -.
DR STRING; 8153.ENSHBUP00000011527; -.
DR Ensembl; ENSHBUT00000018741.1; ENSHBUP00000011527.1; ENSHBUG00000013163.1.
DR GeneID; 102304781; -.
DR CTD; 1409; -.
DR GeneTree; ENSGT00940000160159; -.
DR OMA; QQDDHGY; -.
DR OrthoDB; 3014506at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR GO; GO:0051082; F:unfolded protein binding; IEA:Ensembl.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR003090; Alpha-crystallin_N.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640:SF14; ALPHA-CRYSTALLIN A CHAIN; 1.
DR PANTHER; PTHR45640; HEAT SHOCK PROTEIN HSP-12.2-RELATED; 1.
DR Pfam; PF00525; Crystallin; 1.
DR Pfam; PF00011; HSP20; 1.
DR PIRSF; PIRSF036514; Sm_HSP_B1; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 3: Inferred from homology;
KW Eye lens protein {ECO:0000256|ARBA:ARBA00022613};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR036514-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR036514-1}.
FT DOMAIN 55..165
FT /note="SHSP"
FT /evidence="ECO:0000259|PROSITE:PS01031"
FT REGION 145..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 103
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036514-1"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036514-1"
FT BINDING 110
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR036514-1"
SQ SEQUENCE 176 AA; 19902 MW; F1729CA52C0D5B42 CRC64;
MDIAIQHPWF RRALGSVYPA RLFDQFFGEG MFDYDLFPYA ASTISPYYRQ SLFRNVLDFS
NSGISEVRSD RDKFTVYLDV KHFSPDELSV KVADDYVEIQ GKHGERQDDH GYISREFHRR
YRLPSSVDQS SINCTLSADG LLTLTGPKVS GGSESGRSER SIPVTRDDKP NAAASS
//
