ID   A0A3Q2VJD3_HAPBU        Unreviewed;       981 AA.
AC   A0A3Q2VJD3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Caspase recruitment domain-containing protein 14-like {ECO:0000313|Ensembl:ENSHBUP00000011239.1};
GN   Name=CARD14 {ECO:0000313|Ensembl:ENSHBUP00000011239.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000011239.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000011239.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2VJD3; -.
DR   STRING; 8153.ENSHBUP00000011239; -.
DR   Ensembl; ENSHBUT00000018371.1; ENSHBUP00000011239.1; ENSHBUG00000012841.1.
DR   GeneTree; ENSGT00940000160777; -.
DR   OMA; VVWTEQN; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   CDD; cd08806; CARD_CARD14_CARMA2; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR   PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT   DOMAIN          16..108
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          561..636
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          749..967
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          404..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          133..167
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          220..399
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   981 AA;  110697 MW;  F21CA8F30367F2F2 CRC64;
     MAEECVPEDL DLKGMGEEEL WELINDNRHR ISLGVRPCIL IPYLRQARVL SEMDEDEILS
     CHNLTNRCMR TSHMLDLLRT QGKNGGMALL ESLMIHYPAL YTQVTGRKPS TEPSRFSGLI
     KYSELTEYLV RAVTGMQKEL QEARNEASKL RAHCASLEAD ISQMMEQEMK SRTLRTDNER
     IQRHLCSLQR EVTKLKDEKC DLYIRYTAAI EEKSAVNGRL HELNLQVYQL QTELQNAQAE
     NEFQRQRSLK SVCPESPQLQ DEVRSLRCQL AKAEKLDPAR QDILAQDLAE AIDSQVELAE
     QLRSYREENE QLLRDKKKLL DQNESLSLQV QQLTLDCKMH QQKSAVIQNQ MKALQAERDQ
     AYQSRDEAQA MIAHVLAEKD TLRCQLVELQ EKVFSLQTKC SSTELHQSSE ETEGGWDSLS
     SSSDECPVSS RRRLCRMDAI NPSMVSCSSE CEDGATCSMR SRNAEPPSPD SLRRRKEILY
     AESSSEAAET DSLLDDFVLL PSVVNKSMQT FGLSSRRRSS SHSLSRSSVP PFLMRSRPKA
     IRVSGRVLSI SFQGEALLSQ LAVVGGNKTG VFVHQVTEGS AAHTVGISPG AQIVEVKYEK
     NQKALRMVLE DSTLEEAMWA LGQVAGICHL SLRPRQDDYE ALLQQLQSSE TSSGDSFYVR
     VNMSLPAGPG GTLAVSCNDI LHVTNTRPAG TEDLWHASHV HPCQQLDLQS GTVPNYYRAQ
     RLLIRAIEDM SFEAKKSEKG ERVMTQNTQK TVRIVSTGRQ GRNPLWVSVE EEKSASAESN
     ATSAPKSCVT LMPYTLVTPR YPPVCRPVLL LPSVLGRILD KKLASWQGFQ LCEPEVLSSS
     EHAAQLQRSE ILEEVEQGGS RCYTLQSVEK VMKKGIHCVL PLGLDCVRRL QRSEIFPIII
     FIGQSARSAR KLRSKLHRHS QTEEQLLACS RSEEPLLDKL PCLYHSVDPE SWCDQTSLLT
     SLRTIIWEEQ KKIVWVEPDL W
//