ID A0A3Q2VJF2_HAPBU Unreviewed; 799 AA.
AC A0A3Q2VJF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=AFG3 like matrix AAA peptidase subunit 2 {ECO:0000313|Ensembl:ENSHBUP00000008168.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000008168.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000008168.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR RefSeq; XP_005946480.1; XM_005946418.2.
DR AlphaFoldDB; A0A3Q2VJF2; -.
DR STRING; 8153.ENSHBUP00000008168; -.
DR Ensembl; ENSHBUT00000002412.1; ENSHBUP00000008168.1; ENSHBUG00000009683.1.
DR GeneID; 102311965; -.
DR CTD; 10939; -.
DR GeneTree; ENSGT00940000159566; -.
DR OMA; ARQKGNF; -.
DR OrthoDB; 9585at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655:SF9; AFG3-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..473
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 59..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 88387 MW; 1FF7B06CA536B959 CRC64;
MAHRYLRLSA GCRGLFRLLP PSGAPARLVT SSTTAQVQSG RSLLSDLLGA YRRLSSKPPK
GFEKYFPDSQ KTQKHSEAEA AAKESKPANS QRASGRSTGG GGGAGGGGGG KRGGRKDESH
WYSRLQKGEV PWDDREFRMY FLSGVAFWTT VTYYFFLRDG GREVTWKDFV NNYLSKGVVD
RLEVVNKRYV KVVFSAGKTP ADGQYVWFNI GSVDTFERNL ETAQYELGIE GENRLPVVYS
TESDGTFLLS MLPTVLIIGF LLFMLRRGPA GAGRPGRGMG GLFSVSETTA KILKDEIDVK
FKDVAGCEEA KLEIMEFVNF LKNPKQYQDL GAKIPKGAIL TGPPGTGKTL LAKATAGEAN
VPFITVNGSE FLEMFVGVGP ARVRDLFVMA RKNAPCILFI DEIDAVGRKR GRGNFGGQSE
QENTLNQLLV EMDGFNTATN VVVLAGTNRP DILDPALMRP GRFDRQIYIG PPDIKGRASI
FKVHLRPLKL EPDMDKDSLA RKMAALTPGF SGADIANVCN EAALIAARHL SDAISQKHFE
QAIERVIGGL EKKTQVLQPE EKKTVAYHEA GHAVAGWFLE HADPLLKVSI IPRGKGLGYA
QYLPKEQYLY TKEQLLDRMC MTLGGRVSEE IFFGRITTGA QDDLRKVTQS AYAQIVQFGM
NPKVGQVSFD LPRQGEMVLE KPYSEATARL IDTEVRTLIS EAYQRTQQLL NDKKAEVEKV
AQRLLEKEVL DKNDMVELLG KRPFAEKSTY EEFVEGTGGE DEDTALPEGL KDWNQERRPE
REETPDEQVA RQISGGMPF
//
