ID   A0A3Q2VLA4_HAPBU        Unreviewed;      1142 AA.
AC   A0A3Q2VLA4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Cartilage intermediate layer protein {ECO:0000313|Ensembl:ENSHBUP00000012722.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012722.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000012722.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; A0A3Q2VLA4; -.
DR   Ensembl; ENSHBUT00000032664.1; ENSHBUP00000012722.1; ENSHBUG00000014469.1.
DR   GeneTree; ENSGT00390000008152; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR039675; CILP1/CILP2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR025155; WxxW_domain.
DR   PANTHER; PTHR15031:SF5; CARTILAGE INTERMEDIATE LAYER PROTEIN 1 ISOFORM X1; 1.
DR   PANTHER; PTHR15031; CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF13330; Mucin2_WxxW; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          260..353
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          1092..1142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1092..1108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1127..1142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1142 AA;  128205 MW;  64FC405514840956 CRC64;
     NQVSYLWPYS GLVLLIRVLL LVFFSSFPST HPSQWSTWFN VDHPGGRGDY EQLDAIRFYY
     RTRVCETPKA IEARTTEWIP ARETGETVHA DPTVGFWCLN EEQGPQLNCS NYAVRFLCPK
     GLGTWGPWSD WSPCPALCGQ VGVQLRHRNC QSDSLLCSGP KLDGKACNGP ECPKTACSLQ
     CVMGQANSDC ECMCEEHTML GSVRSAGGLV AKGAAILRSG KFLTLTDHNG HFRIPNICPD
     GNTTLTVRLK GHAPLDVVVP KSKVIFYFCF LEKLHVLSNP ESKVRRAGQS AAFCCKVAGT
     PQPDAYQWFH NNTLMEKESE STLVIRDLHP EQSGEYYCRA SGPTGAIKTK TATLRILDEH
     SCNPKPESHL IRLPHDCFQN STNSFYYDVG KCPPSRCAEQ LDNGIRCKDK VSYCCGVAKM
     EERQLTCQGY QLPTMVVTKC GCQKCVDTKA IVHGRAIAAD NGEPMRFGHI FMNGVRISRT
     GYKGTFSIQI PQDTERLVLT FMDNMQKFVN TTKVLPFNTK GGAVYHEIKL LRKKAPVTIS
     STETNTLELG EVESQEPMVQ IQIPPYSFYK ENGEVFTGNV SASVTFLDPR DISTAAAAQS
     DLNFIGDEGD TMPLRTYGMF SVDFRGEENN EPLNAGEVKV SLDSAQVQMS EHLNTMKLWS
     LNPETGLWEE EGSLQVEKKK RGKREERTFL IGNMEIRERR LFNLDVPENR RCYVKVRAFR
     SERFMPSEQV EGVVISLINM EPKAGYSTNP RAWGRFDSVV TGPNGACLPA FCDEQKADAY
     TAYVMANLGG EELEAVPSAP KFNPNLIGVP QPYLGKLNYM RSDHEDPRVK KTAFSINVAK
     PSPNTAEEGN GPVYPFENLK ECEEAPFSAA HFRFSRVEGD RYDYNTVPFN EDDPMSWTED
     YLSWWPKPME YRACYIKVKI NSPHEINVRS RNMGGTHPKT VGQLYGLRDT RSIRDMDQTS
     VSAVCLEFKC SGMLYDQERV DRTLVKVIPQ GSCKRDHVNS MLQEYLVNHL PLAVNNDTNE
     FTMLAPLDPL GHNYGIYTVT DQDPRTAKEI ALGRCFDGTS DGTSRVMKTN EGIALTFICG
     DREVTRQNVF QTMQRSQGQT VGTSIVRGES RQNRRRQRAN APRSSRRRST RNPEGKRTKA
     RN
//