ID A0A3Q2VM16_HAPBU Unreviewed; 1448 AA.
AC A0A3Q2VM16;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRU {ECO:0000313|Ensembl:ENSHBUP00000013022.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000013022.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000013022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_005941065.1; XM_005941003.2.
DR Ensembl; ENSHBUT00000032789.1; ENSHBUP00000013022.1; ENSHBUG00000015066.1.
DR GeneID; 102308225; -.
DR GeneTree; ENSGT00940000157151; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1448
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018543778"
FT DOMAIN 24..186
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 285..380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 383..485
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 491..591
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 915..1146
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1066..1137
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1178..1441
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1357..1432
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 838..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1448 AA; 163192 MW; 1B6DD9B0DE7466DB CRC64;
MYSAALLLML AIRIYADSME GPTAGCTFDE DSDPGLCEYR QGQEDDFDWQ LIRTYNWPHP
TPDLLRGSFM MVNSSQHYGG QRAQLLLLPL SENDTHCIQF SYFLYSRDGH SPGDLQVYVR
VNSGPKGSAV WNISGSQGRQ WHQVELAVST FWPSEYQVIF EATVSEERQG YIALDDIVLL
NYPCYKVAHF SRLGDVEVNA GQNASFQCVA TGKVSEAEPF LLERRNGVLL DTSMLTRLSH
KRLMATFQVE AQRGEQDLYR CITLSPRGAA VSNFGELIVR VPPTPIAPPQ LLRAGPTYLI
IQLNTNSIVG DGPVIRREIQ YRASQSTWTE THGVGSLTYK VWHLEPDTEY HISVLLTRPG
EGGTGAPGPP LISRTKCAEP MRALRGLTAT EIQPRQLTLQ WEPLGYNLTR CHTYTLSLCY
RYSMPTGGSG GNNATVRECL SVDRNTSHFT LRDLPPFRAV HVRLALANPE GKKESREVTF
QTEEDIPGGI APESLTFTPL DDMIFLKWEE PIEPNGLITQ YEISYQSIES SDPGINVPGP
RRTVSKLRNE TYHMFSGLHP GTTYLVSVRA RTAKGFGQTA LTEITTNISA PVFDYEDIPS
PLSESESTIT VLLRPALGRG APVSAYQVVV VEEDGSRHVK RRELGTVDCF PTPNSHNEAQ
AKGAPHYYTA ELAPSSLPEA TPFTVGDNHT YNGYWNSPLD PTKNYLIYFQ ATSNFRGETR
INCIRIARKA ACKDSKRALE VSQHAEDMGL ILGACAGGLV VLILLLGAIV IIVKKGRDFY
SYPYYPRKKV AINKAAMSYR QEKSRKLSSL DCSMTEQSTL QQDERMAHSF MDAHGCNARN
EQRSSVNESS SLLGGSPQRH CRRKSSPYHT GQLHPAVRVA DLLQHINQMK TAEGYGFKQE
YESFFDGWDV TKKKDKTKGR HDSLLSHDRH RVKLHSLLAD PSSDYVNANY IDGYQRSNHF
IATQGPKQEM IYDFWRMVWQ ENCFSIVMIT KLVEVGRMKC CKYWPDDTEL YGDIKITLLK
TETLAEYTVR TFAMERRGYP AKHEVCQFHF TSWPEHGVPY HATGLLAFLR RVKASTPPDA
GPVVVHCSMG AGRTGCYIVL DVMLDMAECE GVVDIYNCVK TLCSRRINMI QTEEQYVFIH
DAILEACLCG ETAIPVTEFA LTYKEMLKVD SQSNSSQLKE EFQTLNSVTP HLDVEECSIS
LMPRNREKNR SMDVLPPDRS LAFLVTTEGE SSNYINAALA DSFLRPAAFV VTPHPLPGTT
TDFWRLVYDY GCTSVVMLNQ LNQSNSAWPC LQYWPEPGLQ QFGPMTVELL SRTADDDVII
RLFRVQNITR LQEGQLVVRH FQFLRWSPYR DVPDSKKAFL SLLAQVHNWQ RECGEGRTIV
HCLNGGGRSG TFCACTMILE MIRHHSIVDV FFAAKTLRNS KPNMVETMEQ YRFCYDLAQE
YLDCLEVR
//
