ID A0A3Q2VM58_HAPBU Unreviewed; 1219 AA.
AC A0A3Q2VM58;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Glutamate metabotropic receptor 5 {ECO:0000313|Ensembl:ENSHBUP00000012309.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012309.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000012309.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q2VM58; -.
DR Ensembl; ENSHBUT00000019715.1; ENSHBUP00000012309.1; ENSHBUG00000014063.1.
DR GeneTree; ENSGT01030000234595; -.
DR OMA; ECFTPKE; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF30; METABOTROPIC GLUTAMATE RECEPTOR 5; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1219
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018760626"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 579..841
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 988..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 135549 MW; E1C6A006B576930E CRC64;
MFWLLLVLSI WLGPNQADSA QSNERRVVAH MPGDIIIGAL FSVHHQPPAD KVHERKCGAV
REQYGIQRVE AMMHTLDRIN ADPHILPNIS LGCEIRDSCW HSAVALEQSI EFIRDSLVSS
DEAEEWGTLK CSDPSATPMR GKKPIVGLIG PGSSSVAIQV QNLLQLFNIP QIAYSATSMD
LSDKSLYKYF MRVVPSDAQQ ARAMVDIVKR YNWSYVSAIH TEGNYGESGM GAFKDMAAKE
GICIAHSGKI WSNAGEQSFD RLLERLRAHL PKARVVACFC EGMTVRNILM AMRRQGLVGE
FLLIGSDGWA DRYDVTDGYV KEAAGGITIK LQSADVKWFD EYYLKLRPEN NHRNPWFPEF
WQHRFQCRLK GHTQENSKYN RTCSKSLRQQ YAQDTKMGFV INAIYSMAYG LHNMQRSLCP
GYKGLCDAMR PIDGARLLDF LMKTNFTGVS GEGILFDENG DSPGRYEIMN FKKMGKDYYD
YINVGSWDNR GLKIDDDEIW PSKESVIKSV CSDPCDKGQI KVIRKGEVSC CWTCTPCKEN
EFVFDEYTCQ ACELGSWPNN DLTGCDPIPV EYLRWGDPEP IAAVVFACLG LMATFFVTAV
FIRFRDTPVV KSSSRELCYI ILAGICLGYL CTFTLIAKPH VIHCYLQRLG IGLSPAMSYS
ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLIIAFLL ILLQLGIIVA LFLMEPPEVI
HDYPSIRQVN LICNTTNLGV VAPLGYNGLL ILSCTFYAFK TRNVPANFNE AKYIAFTMYT
TCIIWLAFVP IYFGSNYKII TMCFSVSLSA TVALCCMFVP KVYIILAKPE RNVRSAFTTS
TVVRMHVGDG KSSSAASRSS SLVNLWKRRG STGETLRYFC VCGLCVPKSS NGKSVSWAQT
ERSSSRGNHL WQRLSFHIKK KENNQTAVIK PFSKTPEEHY CSGADLPPHV PLPSLPSMSS
LPTHPDNVTD KTLYELSEAE ERYSITYRPQ TPSPISTVSQ RIGASSGEEP QMGSIPKYPS
SICSPQSSLM DQISCVVNRF TANITELNSM MLSSSPSHSH MQKHTPPSPH PADPYLLPRE
LQMPPTLTTY ADVQPLPPVE SSFGGRGGCP IHSMPHSPYP LPPPHSQASQ ASPSRSPMRG
GRLTCLTDSP LRRAELEEEL IALTPPSPFR DSLASSSGSP VSETGLCLPP VPSHPPPSPP
SPRYTRLTLR NYSQSSSSL
//
