ID A0A3Q2VM81_HAPBU Unreviewed; 1780 AA.
AC A0A3Q2VM81;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 1-like {ECO:0000313|Ensembl:ENSHBUP00000012334.1};
GN Name=IQSEC2 {ECO:0000313|Ensembl:ENSHBUP00000012334.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012334.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000012334.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR STRING; 8153.ENSHBUP00000012334; -.
DR Ensembl; ENSHBUT00000032498.1; ENSHBUP00000012334.1; ENSHBUG00000014035.1.
DR GeneTree; ENSGT00940000159667; -.
DR OMA; CHANIGG; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 928..1120
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 50..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1283..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1552..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..91
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..191
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..505
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..757
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..837
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1512
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1724..1755
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1780 AA; 192374 MW; D4735D96A6C5DFE0 CRC64;
MDANQGPGQG SPESPNRAVE YLLELNNIIE SQQKLLETQR RRIEELEVQL DRLSQENKDL
RLDRQPVAPP PPAPPPEPPL PPPPPPPPLA QTTSASISTK NHHHHNSQHQ APAQPPCSIP
LHHQHHQVHH HSSTHHSHSY NSTNSTAPTP IPVPSPTCAP TPHSVLTQIP APISSSAPAA
PPPPPIPPRD QPRAHSRLTR MPSTSTGTNT NFVEKEKERL ERLHRANAAN NHHAHTLHHH
KFVEGDSQCP EALTFSDSSF GHPPPFHRYS NSPLSSPCDP YGSPSSGGPL GASHTHTQGS
SPISPPSPAS LAWAQRSRHQ PASLALRKQE EEESKRCKAL SDSYELSTDL QDKKVEMLER
KYGGPFVSRR AAKTIQTAFR QYRMNKNFER LRSSASESRM TRRIILSNMR MQYSFDERQP
QGQGPPGQQG SEDAGDVDDS FSKQVKSLAD SMDDSLTCQS GREDSQEAGG DGEEDDDEDE
EEGDEEEEEE EEEGEEDEEE DEEEDYRQCA WRNSTTSSRR AAGRTGGGGG RAGAGGGASM
HEDSTATSFS DVTLYMDEGC LPSSPLSRPA SSSDTEYWGG GGGGSAGGRE DSRETEGGSN
TSRRSSTPCT ECRGEYRGRG GGGGHLPVLT IEPPSDSSVD MSDRSERGSI GRLVYEQEPS
GVERGGSGER DRRGGGVEGE SGEDERGGGG GGSSEAESPQ GTIKHKPNGR SVATAQGQTR
SPSNVPLPMP SARTLPSHPL PHPLQHPHPH PSPIPHLPTI LDHHPQYTQH HLMHMHHGHG
GSPYMQHAHH FAQHHYHHLH HQHHHLPHAY PEPPSSPLPS PVPPLTPLSP LPPLTPSPLS
SSSSALQSME AQQHHAHHPH LHHHHLLCSD GDNESVNSTT TNSNDDTTVN NCSSGSSSRD
SLREPIGGAA LGKQTYQRES RHSWDSPAFN NDVVQRRQYR IGLNLFNKKP EKGIQYLIER
GFVSDTPVGI ARFILERKGL SRQMIGEFLG SRQQFNKDVL DCVLDEMDFS GMDLDDALRK
FQAQIKVQGE AQRVERLVEA FSQRYCVCNP VLIRQFQNPD TIFILAFAII LLNTDMYSPN
VKPERKMKLE DFIKNLRGVD NGQDIPRDLL VAIYGRIQKW ELRTNDDHVS QVQAVERMVV
GKKPVLSLPH RRLVCCCQLF EVPDPNRAQR SGVHQREVFL FNDLLMVTKI FQKKKTSVTY
SFRQSFPLVD MQVHTFQNTY YPHGIRLTSA NPGGERKVLI VFNAPSQQDR ARFTSDLRES
IAEVQEMEKY RVESELEKQK GVMRPGVLTG GGPGGMGTQG GGANSGGGTL KSEVVNGTLG
RPSLDDTYAT VDGLKRTALS SSLRDLSETG KRGRRNSVGS LDSTIEGSII SSPRPHQQRP
LPDGGLSYSP IMVPTSPAAY RPHRPTQSPG TGVGGGPGLC HNQGGVTTSP LASGGGVGGG
GGMPAGGGPT GGGRLGNFFG SRRGKVPGPL TMTSPPPQGP PSPLMISSPP HYPAPAPPIP
HPSSPSPCPS PSPNLGQSDS GGVGGGGGTA GAQSKLQALH AQYCHANIGG GGVSVTGHQQ
QQTPPPPYHH HHRYHMQSVP QHHVLSHRFS APRRQGPSGC APSHTQQHQR MQHVIIPHPR
YNMASGFTTP PPLSPHSPVT PITPHGLFHS HPAAGRPGGG AKLPLTISHS QPHPHAHTHS
HNHAVHTHSP LSPSPSASPS THFIFSTPPP QTPSARLVTQ TPPKPYTPQY PPLSSIPPPP
PHSPLPPPST APLSPHPPGV GGGQGGGPKS KPVSRISTVV
//
