UniProt: A0A3Q2VMS4

Database: UniProt
Entry: A0A3Q2VMS4_HAPBU

LinkDB:  A0A3Q2VMS4_HAPBU 
Original site:  A0A3Q2VMS4_HAPBU

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Ontology (5)   
   GO (5)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (21)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (3)   
   SMART (2)   
All databases (31)   

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ID   A0A3Q2VMS4_HAPBU        Unreviewed;      1192 AA.
AC   A0A3Q2VMS4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Integrin subunit alpha 11 {ECO:0000313|Ensembl:ENSHBUP00000013337.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000013337.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000013337.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   RefSeq; XP_014191664.1; XM_014336178.1.
DR   AlphaFoldDB; A0A3Q2VMS4; -.
DR   STRING; 8153.ENSHBUP00000013337; -.
DR   Ensembl; ENSHBUT00000021016.1; ENSHBUP00000013337.1; ENSHBUG00000015202.1.
DR   GeneID; 102298342; -.
DR   CTD; 541475; -.
DR   GeneTree; ENSGT00940000155465; -.
DR   OMA; HGIGPPF; -.
DR   OrthoDB; 3816176at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_A_Ig_1; 1.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 4.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   TRANSMEM        1145..1166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          26..85
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          168..349
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          470..531
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          533..591
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          595..655
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1192 AA;  133708 MW;  E1BE103BEF1D590E CRC64;
     MEYYSFLLLW IYSQQLGFHD CFNIDTKKYR IIKGPKQAQF GYTVQQHVAA GGEKWLLVGA
     PYEMNGAYQT GDVYKCSLSK RTNGNGCAKL NLGRISLTNV SERKDKMRLG MTLTSNPKDN
     SFVACGPLWS YECGSSYYST GICSRVNASF KFSRTIAPAF QRCETYMDIV IVLDGSNSIY
     PWYEVQAFLI NILQKFYIGP GQIQVGVVQY GEKVVHEFKL SDYKSVEEVV KRARSIDQRG
     GEETNTALGI NTARSQAFKH GGRRGAKKVM IVITDGESHD SADLQQAIED SEKDGITRYA
     IAVLGYYNRR GINPEAFLNE IKYIASDPDD KHFFNVTDES ALKDIVDALG ERIFSLEGTS
     KNGTAFGLQM SQAGFSAHSL EDGTLVGAVG AYDWNGAVLK ETRQGKVVPP KLSYAQEFPE
     ELKNHGAYLG YTVTSVVSAR NGRLLVAGAP RFNHTGKVII FTLKNSGNLT ILHSLKGQQI
     GSYYGSEIAP VDIDGDGITD NLLVSAPMFF SAGLEKGKVY IYRVTELNRF FLEGSLEIHN
     GVQNARFGSS LAPVPDLNGD GFNDLVVGAP LEDEHKGAIY IFFSQQNRIL RKYKQRIAAA
     DLAPGLQYFG RSIHGVMDMN DDGLVDLAVG SLGAAVLLWS QSVVRIYTTV RFEPSKINIF
     VKDCQRGGKD VTCMSAIVCF NITARTAISP TQEIGIKYNV SIAEKRYNPR AMLDNPNKMQ
     PQNLTLLPGE ETCEHIYFYV METTDYARPI VFTVQVALQD PENAPVLDDS WPTVVKTELP
     FWNGCDEDDR CIPDLALQSM NDLMTPKQFC AQSVQSRGAF CRRQSEGEME GSLRVLEATR
     RRMVVDVRLE NKGENAYNAR LNITYTPNLH FSSLIVKDNS DIKIECYSQD KLRNEKLCNV
     SAPFMRAKTQ VTFRLEFEFS RTTFLDHLRV ILEASSDGEE NSKADNFNDI YYSLKYEADL
     LFTRDSNPTR YEIKPELSLE EPGIIGPPFN FTFQIQNLGY FPVKDLQLNI EIPEMTKNGN
     QLLQISDFHI NQRDGTHCLP PQHVAQSRAS PEDLSRFSSL NRSNTLTLPI QCTVNVAYYR
     DAAFRITGAL RIDTLHALKF KILELVTSAS VELPSSSPMF LHEERPVRHI ILEIRKEGDY
     RIPTWIIVGS TLGGLLLLAL LSLALWKLGF FQRQKRKEED EQEVNGKVAE ER
//

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