ID A0A3Q2VN75_HAPBU Unreviewed; 1138 AA.
AC A0A3Q2VN75;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A7 {ECO:0000313|Ensembl:ENSHBUP00000012744.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000012744.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000012744.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q2VN75; -.
DR Ensembl; ENSHBUT00000020257.1; ENSHBUP00000012744.1; ENSHBUG00000014454.1.
DR GeneTree; ENSGT00940000157045; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF105; SODIUM BICARBONATE COTRANSPORTER 3; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 501..523
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 588..611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 618..636
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 716..734
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 754..771
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 802..821
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 842..866
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 902..921
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 928..947
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 996..1014
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 142..424
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 472..980
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..74
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 127989 MW; 5A01B4422FA0301B CRC64;
MEEEREQMRP LLTSGNDEEA VLDQGKTSST LYTNFEKEEL ESHRAVYVGV HVPLGRQSRR
RHRHRGHRHH RKRRERSDRE DGRESPSYDT PSQRVQFILG TEDDDEEHIP HDLFTELDEL
AFKDGDMQEW KETARWLKFE EDVEDGGERW SKPYVATLSL HSLFELRSCI LNGTVLLDMR
ASSIEEIADM VIDSMLASGQ LEEGAQEKVR EAMLRRHHHQ NEKKLSNRIP LVRSFADIGK
KYSEPNLLER NGLLASPQSA PGNLDDNKNA ESRGNGGSGS RENSTVDFSK DCDCVCLLPA
ASRKPAVDMN FMKKIPHGAE ASNVLVGEVD FLERPIIAFI RLCPAVLLTG LTEVPVPTRF
LFLLLGPFGK GPQYHEIGRS IATLMTDEVF HDVAYKARDR NDLLSGIDEF LDQVTVLPPG
EWDPSIRIEP PKSVPSQEKR KIASFPNGSA HSSEMGKEAE HHAGPELQRT GRIFGGLVND
VRRKAPFYWS DIRDAVSLQC LASILFLYCA CMSPVITFGG LLGEATKGSI SAIESLFGAS
LTGVAYSLFA GQPLTILGST GPVLVFEKIL FKFCSQYHLS YLHLRTSIGL WTAFLCLLLV
ATDASSLVCY ITRFTEEAFA ALICIIFIYE ALEKLVRLGE LYPINMHNQL DNLTFYRCQC
APPANASAEV LGVWSKQNVT PENITWDQLS SKTCKALMGE LVGPACSHSG PYVPDVLFWS
IILFFTTFFL SSFLKQFKTK SYFPTKVRST ISDFAVFLTI MIMVLVDYLV GVPSPKLNVP
DRFKPTSENR GWLISPLGPN PWWTLLAAAV PALLCTILIF MDQQITAVII NRKENKLKKG
CGYHLDLLVV AVMLGVCSIM GLPWFVAATV LSISHVNSLK LESECAAPGE QPKFLGIREQ
RVTGFMIFFL MGCSVFMTSV LKFIPMPVLY GVFLYMGVSS LKGIQLFDRI KLFGMPAKHQ
PDLIYLRYVP LWKVHVFTVV QLSCLIALWA IKASPAAVIF PMMVLALVFI RKLLDFCFTK
RELSWLDDLI PESKKKKEDD KKKEKEDARR MLEEVEEELP YDRGGVLNFP IKNLKKRDPS
EVNISDEMAK SGIWKSVSKN SDSSKALRRT FSHDKLPSVR INVENEDGQR VVNAETSL
//
