ID   A0A3Q2VQK9_HAPBU        Unreviewed;       625 AA.
AC   A0A3Q2VQK9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=NACHT LRR and PYD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000014527.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000014527.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2VQK9; -.
DR   Ensembl; ENSHBUT00000022537.1; ENSHBUP00000014527.1; ENSHBUG00000016415.1.
DR   GeneTree; ENSGT01100000263513; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF13516; LRR_6; 4.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00367; LRR_CC; 4.
DR   SMART; SM00368; LRR_RI; 6.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        398..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          67..126
FT                   /note="NOD2 winged helix"
FT                   /evidence="ECO:0000259|Pfam:PF17779"
FT   DOMAIN          128..261
FT                   /note="NACHT LRR and PYD"
FT                   /evidence="ECO:0000259|Pfam:PF17776"
SQ   SEQUENCE   625 AA;  70395 MW;  F12631537BEAB8EF CRC64;
     MCHIPVFCWI TATVLEDMLK TREGGQIPVT LTEMYIHFLV VQAKVKNVKY DGGADMDPHW
     SPESRTMVEL LGKLAFEQLQ KSDLIFYESD LAECDTDIRA ASVCSGVFTQ IFKEERGLYQ
     DKVFCFVHLS IQEFLAALHV HLTFISSCVN LLEEQKATSK WSRLSLGKKN LKYLHQSAVN
     KALQSPNGHL DLFLRFLVGL SLQTNQRLLQ GLWTQKRSSS QTNQETVQYI KKKIRKDLSA
     EKSINLFHCL NELNDCSLVE EIQQSLSSGS LSTDKLSPAQ WSALVFILLS SEEDVDVFDL
     KKYSASEEAL LRLLPVVKTS KKCVLCFYLF FLISRLSGCN LSERSCEALS SVFSSKSSSL
     RELDLSNNDL QDSGVKLLSA GVNSPNWKLE TLRSHSRFLV FCLFIFCFFL CLHFFRLSGC
     NISERSCEAL SSFLSSQLSS LREVDLSNNS LQDSGMKILC AESQYWKLET LRSYQVIYFN
     QNHSVLTHFC CKILSNLLRV CNISEGSCEV LSSVLSSQSS NLRELDVSYN SLQDSGMRVL
     SVGMISPHCK VVTLRLSGCN LSERSCETVS SILSSVHSNL RELDLSNNNL QDSGVKLLSI
     GMKCPQCKRN AVILYLVCLL RKILC
//