ID A0A3Q2VRD8_HAPBU Unreviewed; 1939 AA.
AC A0A3Q2VRD8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSHBUP00000014104.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000014104.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000014104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSHBUT00000033240.1; ENSHBUP00000014104.1; ENSHBUG00000016303.1.
DR GeneTree; ENSGT00940000155836; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0000813; C:ESCRT I complex; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR018798; MVB12A/B.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF10240; DUF2464; 1.
DR Pfam; PF13812; PPR_3; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 42..199
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 191..655
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 835..869
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 938..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..967
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1939 AA; 214601 MW; 9A8169A87AB04CA3 CRC64;
MMEDKGPRVA DYFVVAGLTD PSKPLDQEIH FDDVCHKTAR PKAPITDVAV VIRSVGEEVP
PGFTCIETTP TGQSADLNNG ALMAPQILLC YRRGRDKPPL TDLGVLYEWK ERLKQGCHLI
QTTPSGRPAN ISGNSSQRIY ITYRRAPESQ PHAALAVTDV CIIIPSKGET PPHTFCKVEK
NLNSSMWGSS VYLCYKKSVA KTNTIAYKAG LFSRYPEEDY ESFPLPESVP LFCLPMGATI
ECWPANTKYS LPVFSTFVLT GASGEKVYGA AIQFYEPYPQ ECLTDQQLSQ LGLLIPDPHK
PSPSSCMAAG TSSTANGSPR SVYTNKCICL LSHWPFFDAF RKFLTFLYRY SISGPHALPI
EKHISHFMHK VPFPSSQRPR ILVQLSPHDS LMLSQPVSSP LPLSGGRFST LLHNLGPENA
VTLLVFAVTE HKILIHSLRP AVLTSVTEAL VSMIFPFHWP CPYIPLCPLA LADVLSAPCP
FIVGVDSRYF DLYDPPPDVS CVDLDTNTIF HHEDKRALTW KILPKKACKN LMNVLNNLYQ
QLVDGQYRPD GLLELSMSDS SELSCGKSLH TLELEIQEAF LRFMAAILKG YRSFLRPITQ
APSEKATDAS SLFDLQGFLK SRDRSHQKFY SLMTKTQMFI RFIEECSFVS DKDASLAFFD
DCVDKLYNSE RGADKGGKVD SDRPEETRLI EIDESQRSEH TVFITPPELP PLPEGEEHPL
CYRYDGFPVL SLDLFDPVEG LQTPSSRLAA RHSCPTSPAP MFRRTKQEIK SAQKIAKKYS
SIPQLWSKCL LRHCYGLWFI CLPAYVKVCH SKVRALRTAY DVLRKMQAKK LQPPDEVCYR
VLMQLCGQYG QPVLAVRVLF EMKKAGVHPN AITYGYYNKA VLESTWPSST RGGYFLWMKL
RNVILGVAQF KRALRRHAPL TQSPLSGDQS DLGYNSLSKE EVRRGDPAGQ DSAPDKDDKK
ESDCSSLSET ESAKGSKDCL PQLDLEMSSS FRPRGIVRSS CPFDDSACKP KSSASADHVA
GLLFTTSLDE IGEIQTNSLL RRHKSTLEEV VGSASSGSAL DWQGVKSRRL SGDTVGSSGS
GTTVLGLGMS QGETDPDKIA GHLGADAKIL AGANFTKARR PHSLALGGLE GVAAKSHAAR
SSDHREVDEE AERQDSSDED RNTTEAIFDL EDLDFEKPSK GAKPYKKAVE RSASYGGVST
MTNRGTVKRT GIETGYDPLS LLAAESDQQN EERYTEGDQA STPSARRHLA REIELYMNHM
GSPLSSRTPS LDFQDPASPV LLHHSSLSAS SRRASLPHSS PLRTAGVSRS RTFQLPSPSQ
PISRQHLWSS PPTRSLSTTP SPSPRPSPYR ERADRMSLTS PSLSSSSFAL DTLLTPTLDV
FKTSMFSAGK GVAEKASRWY TRLATYTTPT KDSQGDRLSV SSLGAGDPDC SSLLDEEDSG
DTEHSMVFPL RNGPVGPSGP RRSPRRSPLR SHLDSPTAGS SYGRPTSLLP GLPGFSLPDK
SDLSSSRYTS NTSIFNNYAM ELLISSCSRC KTCDCLVYDE EIMAGWTADD SNLNTTCPFC
GNPFLPFLNV EIRDMRGPGR LFLKGSPSVD EATTSSYSAS TGLDTGTSTL STPCPTTAIS
PQSPMIAVQE CSARSRSTRD QGINIPVERR QGALSSGAPI ARSVSAFGPL DETTRHNCCL
PTSGSLPSCL NEATDPLSME WRLHNPEPVT VPYLSPLVLW KELESLLENE GDSVITEADM
VDHHPIIYWN LVWYFRRLDL PSNLPGLILT SEHCNRDSQI PHHWMSEDSK HVLIQILWDN
LKLHQDPIQP LYILWNTYNV GYPVSRPVPE EEKPFSEELL HSMVKSIQRN DVSRPMAQLL
QLLGQTLGVK RQRSLYRDIL FLSLVALGKD NIDIDAFDRE YKLAYDRLTP NLVKLTHNCD
RPPSTGVMEC RRTFGEPYL
//
