ID A0A3Q2VRN3_HAPBU Unreviewed; 1055 AA.
AC A0A3Q2VRN3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Integrin subunit alpha 8 {ECO:0000313|Ensembl:ENSHBUP00000014234.1};
GN Name=ITGA8 {ECO:0000313|Ensembl:ENSHBUP00000014234.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000014234.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000014234.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_005934867.1; XM_005934805.2.
DR AlphaFoldDB; A0A3Q2VRN3; -.
DR STRING; 8153.ENSHBUP00000014234; -.
DR Ensembl; ENSHBUT00000022165.1; ENSHBUP00000014234.1; ENSHBUG00000016072.1.
DR GeneID; 102292808; -.
DR CTD; 8516; -.
DR GeneTree; ENSGT00940000156737; -.
DR OMA; ECLRISC; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1003..1025
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 33..100
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 116..177
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 182..234
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 301..366
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 367..425
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 431..494
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 479..635
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 636..776
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 782..992
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1055 AA; 115796 MW; F0233E5813C8B1D0 CRC64;
MERGWDSVSY AGMCILGVLS VLSSALNGVW GFNFYAEHPT VYRGPDGSYF GYAVDFYQAT
ADSNTISVLV GAPKANTSQP GIVEAGAVYY CPWPGLPESC RQIPFDNSNN RMIKVNGTRE
PLEFKSHQWF GASVRAHRGE VVACAPLYHW RTVKMSGEKD PVGTCYVAVQ NFSAYAEYSP
CRTNDPDPEG QGFCQAGFSV DFTKEGKLVV GGPGSFYWQG QVMTAGIAEI LNGYSLKAVL
RQVSGEKHTR AAEDTHDDSY LGYSVAVGEF TGDSEQELLA GVPRGAQNFG YVAMINSTNM
TFIQNFTGEQ MASYFGYSVA VTDLNGDETD DVLVGAPLFM ERETESKPKE VGRVYLYLQL
APLTFSEPVA LTGTYTFGRF GTAIAPLGDV NQDGYNDVAV GCPFGGEERG GRVLIFNGNK
DISTQGMMLS QELRAAHAPS DSLPGFGFTL RGGQDVDNNQ YPDLIVGAFG VGKVSVYRSQ
AVVSVEAEMI LTPKILNPDD RQCHLPQMNI MVTCLKVNVC AAVSGVGIPS SVDLRAELQL
DWLKGSRGGV KRVLFLDTEQ PQRMGLLRLG HSRPRACLSY TIYLREEDEF RDKLSPISLA
LNYSLAPATL DQSLPPVLNH YSSTFLQEHA YILLDCGDDN ICIPDLQLSA SMDRTEVVIA
DDNLVMLTIT AVNRGEGAYE TELYALLPPE ADYIGVERRV ESLSQLNCEY KLINESRMVV
CDLGNPMVAE TELSVGLRFS VQRLEDAGPK ISFELQIHSS NKDNSDSNLV SLNLSVTAQA
QLDLRGVSHP SQVVLPFPNW EPKEKPIKED DVGPQVTHIY ELHNSGPSSI GEAELHVGWP
SRFRDENLLY AMEIKTDGPV SCRTNTSLNP HGLEISTLQD TPELLGFLRN TSSPPHRHKR
SISTAQDYSN KTLNCTNVSC LKIMCVVGRL DRGQSAVVKI RSRLWAHTFL QRRNDPYILN
STVSFAVTSM PYRIQPATLP QHRSAMGTLV LWGTPDVSFA VPLWVIILAI LLGLLVLAIL
TLAMWKCGFF DRARPPADDD ISDQEKLTSD QTGDA
//