ID A0A3Q2VS36_HAPBU Unreviewed; 401 AA.
AC A0A3Q2VS36;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 10B-like {ECO:0000313|Ensembl:ENSHBUP00000011143.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000011143.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000011143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005948901.1; XM_005948839.2.
DR AlphaFoldDB; A0A3Q2VS36; -.
DR STRING; 8153.ENSHBUP00000011143; -.
DR Ensembl; ENSHBUT00000018240.1; ENSHBUP00000011143.1; ENSHBUG00000012741.1.
DR GeneID; 102292869; -.
DR GeneTree; ENSGT00940000165531; -.
DR OMA; CPADQYE; -.
DR OrthoDB; 3857968at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08315; Death_TRAILR_DR4_DR5; 1.
DR CDD; cd10580; TNFRSF10; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034024; TNFRSF10_N.
DR InterPro; IPR034029; TNFRSF10A/B_death.
DR PANTHER; PTHR46874; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR PANTHER; PTHR46874:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..401
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018766077"
FT TRANSMEM 171..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..118
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 78..118
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 119..159
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 119..159
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 327..392
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 203..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 79..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 97..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 100..118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 120..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 138..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 141..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 401 AA; 45280 MW; 405839F58F132588 CRC64;
MKHVPMFVIS VPVLVLLLKS TTAYPQAGLK VGNGRARRQA NCPADQYEHG NLCCLNCKAG
TYVKSPCSVD GERGQCEECD YDTYMKHDNR LKFCLKCTRC RPDEEIVSSC THTEDTKCQC
KPGRFCDPNQ ACEVCLKCSR CAEDEEKVRN CTSTTNTECK KIQNKSGSDP GITVVVVVVV
LFVLAAITFA GIFFYKRRRK MGSQRNRSGR SKAEQQYTAI QTPEDKDTQR PTSTNLILSQ
HLVRVQSSNI AEDERQFLNP SFNSSASNSQ HSLTDALTPA PQASPVVSAQ LHRREEVPLP
KLVPVNGEES LRKCFEYFEE LDVNYQKRFF RQLEISDNVI KSKENLPYED RIHELLHIWV
EKEGKGASLN DLLQALNILN QRRTAETIHQ KAVDGGHFLL L
//
